Screening for PPAR Responsive Regulatory Modules in Cancer
Figure 2
Possible evolutionary changes to PPRE location, strength, and conservation. Hypothetical
genes from two different species (e.g., human and mouse) were compared for
their PPREs (black bars, their height indicates relative strength). When the
PPRE pattern is preserved, the genes will be sorted into cluster I, when
extended in cluster II, when replaced in cluster III and when not at all
conserved (e.g., when turned-over) in cluster IV.