Review Article

Screening for PPAR Responsive Regulatory Modules in Cancer

Figure 2

Possible evolutionary changes to PPRE location, strength, and conservation. Hypothetical genes from two different species (e.g., human and mouse) were compared for their PPREs (black bars, their height indicates relative strength). When the PPRE pattern is preserved, the genes will be sorted into cluster I, when extended in cluster II, when replaced in cluster III and when not at all conserved (e.g., when turned-over) in cluster IV.
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