Species
differences in lipase activities (pmol/mg protein in microsomal fragment/min)
using hepatic microsomes in liver, small intestine, kidney, and lung from mice,
rats, and marmosets. Lipase activity was measured by GC/MS. Substrate
concentration (DEHP) used was 1 mM. Each white bar (6 mice), grey bar (5 rats),
or black bar (5 marmosets) represents the mean standard deviations. Lipase
activity was not detected in marmoset lung (under 1 pmol/mg protein/min).
Comparisons were made using analysis of variance and the Tukey-Kramer HSD post hoc
test. A logarithmic transformation was applied to lipase activities in
microsome samples from the small intestine and kidneys before Tukey-Kramer
analysis. Different letters (a, b, c) on the top of each bar in each organ indicate
that they are significantly different from each other (P < .05).
