PPAR Research
Volume 2008 (2008), Article ID 780452, 10 pages
doi:10.1155/2008/780452
Review Article
Peroxisome Proliferator-Activated Receptor β/δ in the Brain: Facts and Hypothesis
Center of Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, 1015 Lausanne, Switzerland
Received 8 August 2008; Accepted 8 September 2008
Academic Editor: Francine M. Gregoire
Copyright © 2008 M. G. Hall et al. This is an open access article distributed under the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- D. J. Mangelsdorf, C. Thummel, M. Beato, et al., “The nuclear receptor superfamily: the second decade,” Cell, vol. 83, no. 6, pp. 835–839, 1995. View at Publisher · View at Google Scholar
- A. L. Bookout, Y. Jeong, M. Downes, R. T. Yu, R. M. Evans, and D. J. Mangelsdorf, “Anatomical profiling of nuclear receptor expression revealsa hierarchical transcriptional network,” Cell, vol. 126, no. 4, pp. 789–799, 2006. View at Publisher · View at Google Scholar · View at PubMed
- A. Chawla, J. J. Repa, R. M. Evans, and D. J. Mangelsdorf, “Nuclear receptors and lipid physiology: opening the X-files,” Science, vol. 294, no. 5548, pp. 1866–1870, 2001. View at Publisher · View at Google Scholar · View at PubMed
- F. Gofflot, N. Chartoire, L. Vasseur, et al., “Systematic gene expression mapping clusters nuclear receptors according to their function in the brain,” Cell, vol. 131, no. 2, pp. 405–418, 2007. View at Publisher · View at Google Scholar · View at PubMed
- J. N. Feige, L. Gelman, L. Michalik, B. Desvergne, and W. Wahli, “From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions,” Progress in Lipid Research, vol. 45, no. 2, pp. 120–159, 2006. View at Publisher · View at Google Scholar · View at PubMed
- O. Braissant, F. Foufelle, C. Scotto, M. Dauca, and W. Wahli, “Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-, -, and - in the adult rat,” Endocrinology, vol. 137, no. 1, pp. 354–366, 1996. View at Publisher · View at Google Scholar
- J. M. Peters, S. S. T. Lee, W. Li, et al., “Growths, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor (),” Molecular and Cellular Biology, vol. 20, no. 14, pp. 5119–5128, 2000. View at Publisher · View at Google Scholar
- C. Dreyer, G. Krey, H. Keller, F. Givel, G. Helftenbein, and W. Wahli, “Control of the peroxisomal -oxidation pathway by a novel family of nuclear hormone receptors,” Cell, vol. 68, no. 5, pp. 879–887, 1992. View at Publisher · View at Google Scholar
- I. Issemann and S. Green, “Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators,” Nature, vol. 347, no. 6294, pp. 645–650, 1990. View at Publisher · View at Google Scholar · View at PubMed
- S. A. Kliewer, B. M. Forman, B. Blumberg, et al., “Differential expression and activation of a family of murine peroxisome proliferator-activated receptors,” Proceedings of the National Academy of Sciences of the United States of America, vol. 91, no. 15, pp. 7355–7359, 1994. View at Publisher · View at Google Scholar
- Y. Barak, D. Liao, W. He, et al., “Effects of peroxisome proliferator-activated receptor on placentation, adiposity, and colorectal cancer,” Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 1, pp. 303–308, 2002. View at Publisher · View at Google Scholar · View at PubMed
- K. Nadra, S. I. Anghel, E. Joye, et al., “Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor /,” Molecular and Cellular Biology, vol. 26, no. 8, pp. 3266–3281, 2006. View at Publisher · View at Google Scholar · View at PubMed
- L. Michalik, B. Desvergne, N. S. Tan, et al., “Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR) and PPAR mutant mice,” Journal of Cell Biology, vol. 154, no. 4, pp. 799–814, 2001. View at Publisher · View at Google Scholar · View at PubMed
- F. Varnat, B. B. Heggeler, P. Grisel, et al., “PPAR/ regulates paneth cell differentiation via controlling the hedgehog signaling pathway,” Gastroenterology, vol. 131, no. 2, pp. 538–553, 2006. View at Publisher · View at Google Scholar · View at PubMed
- E. Bedu, D. Desplanches, J. Pequignot, B. Bordier, and B. Desvergne, “Double gene deletion reveals the lack of cooperation between PPAR and PPAR in skeletal muscle,” Biochemical and Biophysical Research Communications, vol. 357, no. 4, pp. 877–881, 2007. View at Publisher · View at Google Scholar · View at PubMed
- N. S. Tan, G. Icre, A. Montagner, B. Bordier-Ten Heggeler, W. Wahli, and L. Michalik, “The nuclear hormone receptor peroxisome proliferator-activated receptor / potentiates cell chemotactism, polarization, and migration,” Molecular and Cellular Biology, vol. 27, no. 20, pp. 7161–7175, 2007. View at Publisher · View at Google Scholar · View at PubMed
- O. Braissant and W. Wahli, “Differential expression of peroxisome proliferator-activated receptor-, -, and - during rat embryonic development,” Endocrinology, vol. 139, no. 6, pp. 2748–2754, 1998. View at Publisher · View at Google Scholar
- G. Q. Xing, L. X. Zhang, L. Zhang, et al., “Rat PPAR contains a CGG triplet repeat and is prominently expressed in the thalamic nuclei,” Biochemical and Biophysical Research Communications, vol. 217, no. 3, pp. 1015–1025, 1995. View at Publisher · View at Google Scholar
- J. W. Woods, M. Tanen, D. J. Figueroa, et al., “Localization of PPAR in murine central nervous system: expression in oligodendrocytes and neurons,” Brain Research, vol. 975, no. 1-2, pp. 10–21, 2003. View at Publisher · View at Google Scholar
- A. Cimini, E. Benedetti, L. Cristiano, et al., “Expression of peroxisome proliferator-activated receptors (PPARs) and retinoic acid receptors (RXRs) in rat cortical neurons,” Neuroscience, vol. 130, no. 2, pp. 325–337, 2005. View at Publisher · View at Google Scholar · View at PubMed
- H. Higashiyama, A. N. Billin, Y. Okamoto, M. Kinoshita, and S. Asano, “Expression profiling of peroxisome proliferator-activated receptor-delta (PPAR-delta) in mouse tissues using tissue microarray,” Histochemistry and Cell Biology, vol. 127, no. 5, pp. 485–494, 2007. View at Publisher · View at Google Scholar · View at PubMed
- S. Moreno, S. Farioli-vecchioli, and M. P. Cerù, “Immunolocalization of peroxisome proliferator-activated receptors and retinoid X receptors in the adult rat CNS,” Neuroscience, vol. 123, no. 1, pp. 131–145, 2004. View at Publisher · View at Google Scholar
- L. Cristiano, A. Bernardo, and M. P. Cerù, “Peroxisome proliferator-activated receptors (PPARs) and peroxisomes in rat cortical and cerebellar astrocytes,” Journal of Neurocytology, vol. 30, no. 8, pp. 671–683, 2001. View at Publisher · View at Google Scholar
- L. Cristiano, A. Cimini, S. Moreno, A. M. Ragnelli, and M. P. Cerù, “Peroxisome proliferator-activated receptors (PPARs) and related transcription factors in differentiating astrocyte cultures,” Neuroscience, vol. 131, no. 3, pp. 577–587, 2005. View at Publisher · View at Google Scholar · View at PubMed
- S. Akanuma, S. Hori, S. Ohtsuki, M. Fujiyoshi, and T. Terasaki, “Expression of nuclear receptor mRNA and liver X receptor-mediated regulation of ABC transporter A1 at rat blood-brain barrier,” Neurochemistry International, vol. 52, no. 4-5, pp. 669–674, 2008. View at Publisher · View at Google Scholar · View at PubMed
- E. E. Girroir, H. E. Hollingshead, P. He, B. Zhu, G. H. Perdew, and J. M. Peters, “Quantitative expression patterns of peroxisome proliferator-activated receptor-/ (PPAR/) protein in mice,” Biochemical and Biophysical Research Communications, vol. 371, no. 3, pp. 456–461, 2008. View at Publisher · View at Google Scholar · View at PubMed
- F. Bogazzi, L. D. Hudson, and V. M. Nikodem, “A novel heterodimerization partner for thyroid hormone receptor. Peroxisome proliferator-activated receptor,” The Journal of Biological Chemistry, vol. 269, no. 16, pp. 11683–11686, 1994.
- P. A. Grimaldi, “Regulatory functions of PPAR in metabolism: implications for the treatment of metabolic syndrome,” Biochimica et Biophysica Acta, vol. 1771, no. 8, pp. 983–990, 2007. View at Publisher · View at Google Scholar · View at PubMed
- Y.-X. Wang, C.-H. Lee, S. Tiep, et al., “Peroxisome-proliferator-activated receptor activates fat metabolism to prevent obesity,” Cell, vol. 113, no. 2, pp. 159–170, 2003. View at Publisher · View at Google Scholar
- C.-H. Lee, P. Olson, A. Hevener, et al., “PPAR regulates glucose metabolism and insulin sensitivity,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 9, pp. 3444–3449, 2006. View at Publisher · View at Google Scholar · View at PubMed
- T. A. Rosenberger, J. T. Hovda, and J. M. Peters, “Targeted disruption of peroxisomal proliferator-activated receptor () results in distinct gender differences in mouse brain phospholipid and esterified FA levels,” Lipids, vol. 37, no. 5, pp. 495–500, 2002. View at Publisher · View at Google Scholar
- S. Huyghe, H. Schmalbruch, K. De Gendt, et al., “Peroxisomal multifunctional protein 2 is essential for lipid homeostasis in Sertoli cells and male fertility in mice,” Endocrinology, vol. 147, no. 5, pp. 2228–2236, 2006. View at Publisher · View at Google Scholar · View at PubMed
- S. Basu-Modak, O. Braissant, P. Escher, B. Desvergne, P. Honegger, and W. Wahli, “Peroxisome proliferator-activated receptor regulates acyl-CoA synthetase 2 in reaggregated rat brain cell cultures,” The Journal of Biological Chemistry, vol. 274, no. 50, pp. 35881–35888, 1999. View at Publisher · View at Google Scholar
- A. T. Campagnoni and W. B. Macklin, “Cellular and molecular aspects of myelin protein gene expression,” Molecular Neurobiology, vol. 2, no. 1, pp. 41–89, 1988. View at Publisher · View at Google Scholar
- X. Huang, Y. Litingtung, and C. Chiang, “Ectopic sonic hedgehog signaling impairs telencephalic dorsal midline development: implication for human holoprosencephaly,” Human Molecular Genetics, vol. 16, no. 12, pp. 1454–1468, 2007. View at Publisher · View at Google Scholar · View at PubMed
- M. D. Leibowitz, C. Fiévet, N. Hennuyer, et al., “Activation of PPAR alters lipid metabolism in db/db mice,” FEBS Letters, vol. 473, no. 3, pp. 333–336, 2000. View at Publisher · View at Google Scholar
- W. R. Oliver, Jr., J. L. Shenk, M. R. Snaith, et al., “A selective peroxisome proliferator-activated receptor agonist promotes reverse cholesterol transport,” Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 9, pp. 5306–5311, 2001. View at Publisher · View at Google Scholar · View at PubMed
- H. Vosper, L. Patel, T. L. Graham, et al., “The peroxisome proliferator-activated receptor promotes lipid accumulation in human macrophages,” The Journal of Biological Chemistry, vol. 276, no. 47, pp. 44258–44265, 2001. View at Publisher · View at Google Scholar · View at PubMed
- M.-Q. Man, E.-H. Choi, M. Schmuth, et al., “Basis for improved permeability barrier homeostasis induced by PPAR and LXR activators: liposensors stimulate lipid synthesis, lamellar body secretion, and post-secretory lipid processing,” Journal of Investigative Dermatology, vol. 126, no. 2, pp. 386–392, 2006. View at Publisher · View at Google Scholar · View at PubMed
- Y. J. Jiang, P. Kim, P. M. Elias, and K. R. Feingold, “LXR and PPAR activators stimulate cholesterol sulfotransferase type 2 isoform 1b in human keratinocytes,” Journal of Lipid Research, vol. 46, no. 12, pp. 2657–2666, 2005. View at Publisher · View at Google Scholar · View at PubMed
- J. M. Dietschy and S. D. Turley, “Thematic review series: brain lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal,” Journal of Lipid Research, vol. 45, no. 8, pp. 1375–1397, 2004. View at Publisher · View at Google Scholar · View at PubMed
- C. Bastie, D. Holst, D. Gaillard, C. Jehl-Pietri, and P. A. Grimaldi, “Expression of peroxisome proliferator-activated receptor PPAR promotes induction of PPAR and adipocyte differentiation in 3T3C2 fibroblasts,” The Journal of Biological Chemistry, vol. 274, no. 31, pp. 21920–21925, 1999. View at Publisher · View at Google Scholar
- J. N. Feige, L. Gelman, D. Rossi, et al., “The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor modulator that promotes adipogenesis,” The Journal of Biological Chemistry, vol. 282, no. 26, pp. 19152–19166, 2007. View at Publisher · View at Google Scholar · View at PubMed
- N. S. Tan, L. Michalik, N. Noy, et al., “Critical roles of PPAR/ in keratinocyte response to inflammation,” Genes & Development, vol. 15, no. 24, pp. 3263–3277, 2001. View at Publisher · View at Google Scholar · View at PubMed
- A. Cimini, L. Cristiano, E. Benedetti, B. D'Angelo, and M. P. Cerù, “PPARs expression in adult mouse neural stem cells: modulation of PPARs during astroglial differentiaton of NSC,” PPAR Research, vol. 2007, Article ID 48242, 10 pages, 2007. View at Publisher · View at Google Scholar · View at PubMed
- I. Saluja, J. G. Granneman, and R. P. Skoff, “PPAR agonists stimulate oligodendrocyte differentiation in tissue culture,” Glia, vol. 33, no. 3, pp. 191–204, 2001. View at Publisher · View at Google Scholar
- J. Granneman, R. Skoff, and X. Yang, “Member of the peroxisome proliferator-activated receptor family of transcription factors is differentially expressed by oligodendrocytes,” Journal of Neuroscience Research, vol. 51, no. 5, pp. 563–573, 1998. View at Publisher · View at Google Scholar
- B. A. Barres, M. A. Lazar, and M. C. Raff, “A novel role for thyroid hormone, glucocorticoids and retinoic acid in timing oligodendrocyte development,” Development, vol. 120, no. 5, pp. 1097–1108, 1994.
- J. W. DeWille and S. J. Farmer, “Postnatal dietary fat influences mRNAS involved in myelination,” Developmental Neuroscience, vol. 14, no. 1, pp. 61–68, 1992.
- S. Salvati, M. Sanchez, L. M. Campeggi, G. Suchanek, H. Breitschop, and H. Lassmann, “Accelerated myelinogenesis by dietary lipids in rat brain,” Journal of Neurochemistry, vol. 67, no. 4, pp. 1744–1750, 1996.
- P. A. Grimaldi, “The roles of PPARs in adipocyte differentiation,” Progress in Lipid Research, vol. 40, no. 4, pp. 269–281, 2001. View at Publisher · View at Google Scholar
- R. L. Rosenfield, A. Kentsis, D. Deplewski, and N. Ciletti, “Rat preputial sebocyte differentiation involves peroxisome proliferator-activated receptors,” Journal of Investigative Dermatology, vol. 112, no. 2, pp. 226–232, 1999. View at Publisher · View at Google Scholar · View at PubMed
- M. Schmuth, C. M. Haqq, W. J. Cairns, et al., “Peroxisome proliferator-activated receptor (PPAR)-/ stimulates differentiation and lipid accumulation in keratinocytes,” Journal of Investigative Dermatology, vol. 122, no. 4, pp. 971–983, 2004. View at Publisher · View at Google Scholar · View at PubMed
- L. Michalik and W. Wahli, “Peroxisome proliferator-activated receptors (PPARs) in skin health, repair and disease,” Biochimica et Biophysica Acta, vol. 1771, no. 8, pp. 991–998, 2007. View at Publisher · View at Google Scholar · View at PubMed
- S. Di Loreto, B. D'Angelo, M. A. D'Amico, et al., “PPAR agonists trigger neuronal differentiation in the human neuroblastoma cell line SH-SY5Y,” Journal of Cellular Physiology, vol. 211, no. 3, pp. 837–847, 2007. View at Publisher · View at Google Scholar · View at PubMed
- A. Cimini and M. P. Cerù, “Emerging roles of peroxisome proliferator-activated receptors (PPARs) in the regulation of neural stem cells proliferation and differentiation,” to appear in Stem Cell Reviews 2008 Jun 17 Epub ahead of print.
- J. Zhang, M. Fu, X. Zhu, et al., “Peroxisome proliferator-activated receptor is up-regulated during vascular lesion formation and promotes post-confluent cell proliferation in vascular smooth muscle cells,” The Journal of Biological Chemistry, vol. 277, no. 13, pp. 11505–11512, 2002. View at Publisher · View at Google Scholar · View at PubMed
- J. B. Hansen, H. Zhang, T. H. Rasmussen, R. K. Petersen, E. N. Flindt, and K. Kristiansen, “Peroxisome proliferator-activated receptor (PPAR)-mediated regulation of preadipocyte proliferation and gene expression is dependent on cAMP signaling,” The Journal of Biological Chemistry, vol. 276, no. 5, pp. 3175–3182, 2001. View at Publisher · View at Google Scholar · View at PubMed
- C. Jehl-Pietri, C. Bastie, I. Gillot, S. Luquet, and P. A. Grimaldi, “Peroxisome-proliferator-activated receptor mediates the effects of long-chain fatty acids on post-confluent cell proliferation,” Biochemical Journal, vol. 350, no. 1, pp. 93–98, 2000. View at Publisher · View at Google Scholar
- N. Di-Poï, L. Michalik, N. S. Tan, B. Desvergne, and W. Wahli, “The anti-apoptotic role of PPAR contributes to efficient skin wound healing,” The Journal of Steroid Biochemistry and Molecular Biology, vol. 85, no. 2–5, pp. 257–265, 2003. View at Publisher · View at Google Scholar
- D. Arsenijevic, F. de Bilbao, J. Plamondon, et al., “Increased infarct size and lack of hyperphagic response after focal cerebral ischemia in peroxisome proliferator-activated receptor -deficient mice,” Journal of Cerebral Blood Flow & Metabolism, vol. 26, no. 3, pp. 433–445, 2006. View at Publisher · View at Google Scholar · View at PubMed
- J.-B. Pialat, T.-H. Cho, O. Beuf, et al., “MRI monitoring of focal cerebral ischemia in peroxisome proliferator-activated receptor (PPAR)-deficient mice,” NMR in Biomedicine, vol. 20, no. 3, pp. 335–342, 2007. View at Publisher · View at Google Scholar · View at PubMed
- A. Iwashita, Y. Muramatsu, T. Yamazaki, et al., “Neuroprotective efficacy of the peroxisome proliferator-activated receptor -selective agonists in vitro and in vivo,” Journal of Pharmacology and Experimental Therapeutics, vol. 320, no. 3, pp. 1087–1096, 2007. View at Publisher · View at Google Scholar · View at PubMed
- N. Di-Poï, N. S. Tan, L. Michalik, W. Wahli, and B. Desvergne, “Antiapoptotic role of PPAR in keratinocytes via transcriptional control of the Akt1 signaling pathway,” Molecular Cell, vol. 10, no. 4, pp. 721–733, 2002. View at Publisher · View at Google Scholar
- C.-M. Hao, R. Redha, J. Morrow, and M. D. Breyer, “Peroxisome proliferator-activated receptor activation promotes cell survival following hypertonic stress,” The Journal of Biological Chemistry, vol. 277, no. 24, pp. 21341–21345, 2002. View at Publisher · View at Google Scholar · View at PubMed
- E. Letavernier, J. Perez, E. Joye, et al., “Peroxisome proliferator-activated receptor / exerts a strong protection from ischemic acute renal failure,” Journal of the American Society of Nephrology, vol. 16, no. 8, pp. 2395–2402, 2005. View at Publisher · View at Google Scholar · View at PubMed
- S. A. Smith, G. R. Monteith, J. A. Robinson, N. G. Venkata, F. J. May, and S. J. Roberts-Thomson, “Effect of the peroxisome proliferator-activated receptor activator GW0742 in rat cultured cerebellar granule neurons,” Journal of Neuroscience Research, vol. 77, no. 2, pp. 240–249, 2004. View at Publisher · View at Google Scholar · View at PubMed
- H. E. Hollingshead, M. G. Borland, A. N. Billin, T. M. Willson, F. J. Gonzalez, and J. M. Peters, “Ligand activation of peroxisome proliferator-activated receptor-/ (PPAR/) and inhibition of cyclooxygenase 2 (COX2) attenuate colon carcinogenesis through independent signaling mechanisms,” Carcinogenesis, vol. 29, no. 1, pp. 169–176, 2008. View at Publisher · View at Google Scholar · View at PubMed
- L. Minghetti, “Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases,” Journal of Neuropathology and Experimental Neurology, vol. 63, no. 9, pp. 901–910, 2004.
- P. E. Polak, S. Kalinin, C. Dello Russo, et al., “Protective effects of a peroxisome proliferator-activated receptor-/ agonist in experimental autoimmune encephalomyelitis,” Journal of Neuroimmunology, vol. 168, no. 1-2, pp. 65–75, 2005. View at Publisher · View at Google Scholar · View at PubMed
- C.-H. Lee, A. Chawla, N. Urbiztondo, D. Liao, W. A. Boisvert, and R. M. Evans, “Transcriptional repression of atherogenic inflammation: modulation by PPAR,” Science, vol. 302, no. 5644, pp. 453–457, 2003. View at Publisher · View at Google Scholar · View at PubMed
- S. Müller-Brüsselbach, M. Kömhoff, M. Rieck, et al., “Deregulation of tumor angiogenesis and blockade of tumor growth in PPAR-deficient mice,” The EMBO Journal, vol. 26, no. 15, pp. 3686–3698, 2007. View at Publisher · View at Google Scholar · View at PubMed
- Y. Fan and G.-Y. Yang, “Therapeutic angiogenesis for brain ischemia: a brief review,” Journal of Neuroimmune Pharmacology, vol. 2, no. 3, pp. 284–289, 2007. View at Publisher · View at Google Scholar · View at PubMed
- G. J. del Zoppo, R. Milner, T. Mabuchi, S. Hung, X. Wang, and J. A. Koziol, “Vascular matrix adhesion and the blood-brain barrier,” Biochemical Society Transactions, vol. 34, no. 6, pp. 1261–1266, 2006. View at Publisher · View at Google Scholar · View at PubMed
- G. J. del Zoppo and R. Milner, “Integrin-matrix interactions in the cerebral microvasculature,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 26, no. 9, pp. 1966–1975, 2006. View at Publisher · View at Google Scholar · View at PubMed
- A. Lampen, P. A. Grimaldi, and H. Nau, “Modulation of peroxisome proliferator-activated receptor activity affects neural cell adhesion molecule and polysialyltransferase ST8SiaIV induction by teratogenic valproic acid analogs in F9 cell differentiation,” Molecular Pharmacology, vol. 68, no. 1, pp. 193–203, 2005. View at Publisher · View at Google Scholar · View at PubMed
- Y. Fan, Y. Wang, Z. Tang, et al., “Suppression of pro-inflammatory adhesion molecules by PPAR- in human vascular endothelial cells,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 28, no. 2, pp. 315–321, 2008. View at Publisher · View at Google Scholar · View at PubMed
- D. Chaturvedi, S. Ray, A. K. Srivastava, and R. Chander, “-(2-Naphthyloxy) amino alkanes as a novel class of anti-hyperglycemic and lipid lowering agents,” Bioorganic & Medicinal Chemistry, vol. 16, no. 5, pp. 2489–2498, 2008. View at Publisher · View at Google Scholar · View at PubMed
- M. K. Storch, A. Stefferl, U. Brehm, et al., “Autoimmunity to myelin oligodendrocyte glycoprotein in rats mimics the spectrum of multiple sclerosis pathology,” Brain Pathology, vol. 8, no. 4, pp. 681–694, 1998.
- T. G. Johns, N. Kerlero de Rosbo, K. K. Menon, S. Abo, M. F. Gonzales, and C. C. Bernard, “Myelin oligodendrocyte glycoprotein induces a demyelinating encephalomyelitis resembling multiple sclerosis,” The Journal of Immunology, vol. 154, no. 10, pp. 5536–5541, 1995.
- S. Schmidt, E. Moric, M. Schmidt, M. Sastre, D. L. Feinstein, and M. T. Heneka, “Anti-inflammatory and antiproliferative actions of PPAR- agonists on T lymphocytes derived from MS patients,” Journal of Leukocyte Biology, vol. 75, no. 3, pp. 478–485, 2004. View at Publisher · View at Google Scholar · View at PubMed
- H. Rampler, I. Weinhofer, A. Netik, et al., “Evaluation of the therapeutic potential of PPAR agonists for X-linked adrenoleukodystrophy,” Molecular Genetics and Metabolism, vol. 80, no. 4, pp. 398–407, 2003. View at Publisher · View at Google Scholar
- E. Galea, M. T. Heneka, C. Dello Russo, and D. L. Feinstein, “Intrinsic regulation of brain inflammatory responses,” Cellular and Molecular Neurobiology, vol. 23, no. 4-5, pp. 625–635, 2003. View at Publisher · View at Google Scholar
- M. Seimandi, G. Lemaire, A. Pillon, et al., “Differential responses of PPAR, PPAR, and PPAR reporter cell lines to selective PPAR synthetic ligands,” Analytical Biochemistry, vol. 344, no. 1, pp. 8–15, 2005. View at Publisher · View at Google Scholar · View at PubMed
- J. L. M. Madrigal, S. Kalinin, J. C. Richardson, and D. L. Feinstein, “Neuroprotective actions of noradrenaline: effects on glutathione synthesis and activation of peroxisome proliferator activated receptor delta,” Journal of Neurochemistry, vol. 103, no. 5, pp. 2092–2101, 2007. View at Publisher · View at Google Scholar · View at PubMed