The Role of PPAR𝜸 in the Cyclooxygenase Pathway in Lung Cancer

Table 1

Off-target effects of TZDs in NSCLC.

Thiazolidinediones	Molecular effects	Mechanisms	Reference
Troglitazone	↑ PGE2	↑ COX-2, ERK and PI3K phosphorylation	[62]
Pioglitazone, Rosiglitazone	↓ PGE2	↑ 15-PGDH	[14]
Ciglitazone	↓PGE2	↓ COX-2	[13]