Role of Peroxisome Proliferator-Activated Receptor Gamma and Its Ligands in the Treatment of Hematological Malignancies

<table><i> Mechanisms of action of PPAR<span class="inline" id=""></span> ligands in hematological malignancies.</i> PPAR<span class="inline" id=""></span> ligands can bind to and activate PPAR<span class="inline" id=""></span>
to regulate gene transcription or they can exert PPAR<span class="inline" id=""></span>-independent mechanisms.
PPAR<span class="inline" id=""></span> ligands have antiproliferative,
prodifferentiation, antimetastatic, and proapoptotic effects on several
hematological malignancies making them promising candidates for use in
therapeutic regimens.</table>

PPAR Research

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Figure 3

Figure 3: Role of Peroxisome Proliferator-Activated Receptor Gamma and Its Ligands in the Treatment of Hematological Malignancies 