Regulation of Lymphocyte Function by PPAR: Relevance to Thyroid Eye Disease-Related Inflammation
Figure 2
T lymphocytes in TED patients express constitutively elevated levels of Cox-2,
one enzyme critical to the production of the naturally-occurring PPAR ligand 15d-PGJ2. When these lymphocytes infiltrate the orbit, 15d-PGJ2is secreted in resident fibroblasts result in their differentiation into adipocytes.
