The Role of PPARs in the Endothelium: Implications for Cancer Therapy

Figure 4

Endothelial PPARβ/δ has predominantly proangiogenic actions on endothelial cells. The majority of studies so far indicate that PPARβ/δ activation induces (solid line) proangiogenic factors, while reduces (broken line) antiangiogenic factors. Similar to PPARα and PPARγ, PPARβ/δ also appears to be anti-inflammatory by reducing proinflammatory pathways and potentially anticoagulant by reducing tissue factor release.