PPAR𝛾, PTEN, and the Fight against Cancer

Figure 2

PTEN promoter and its transcription factors. PTEN’s full-length promoter lies between −1344 and −745 (gray bar), while the minimal promoter lies between −958 and −821 (black bar). Four transcription factors are known to directly bind upstream of PTEN: PPARγ (solid gray bar), USF1 (stripped gray bar), p53 (dotted gray bar), and EGR1 (dashed gray bar).