The Effects of Thiazolidinediones on Metabolic Complications and Lipodystrophy in HIV-Infected Patients

Table 2

Body composition data from thiazolidinedione studies which included a control arm and an objective measurement of body composition in HIV-infected, HAART-treated patients. HAART = highly active antiretroviral therapy, SAT = subcutaneous adipose tissue, NS = nonsignificant, MRI = magnetic resonance imaging, DEXA = dual-energy X-ray absorptiometry, CT = computed tomography, s.c. = subcutaneous, ND = not done, CI = confidence interval.

	𝑁	Drug	Duration	Subcutaneous adipose tissue	Visceral adipose tissue	Body mass index (kg/m^2)	Reference
No change in SAT	30	Rosi versus placebo	24 weeks	MRI: NS	MRI: NS	NS	Sutinen et al. [55]
	108	Rosi versus placebo	48 weeks	DEXA  limb  fat:  NS CT  thigh:  NS CT  s.c.  abdomen:  NS	CT: NS	NS	Carr et al. [56]
	14	Pio versus feno versus pio + feno versus placebo	12 months	DEXA  upper  limb  fat:  NS DEXA  lower  limb  fat:  NS CT  s.c.  abdomen:  NS	CT: NS	NS	Gavrila et al. [65]
	96	Rosi versus placebo	24 weeks	DEXA limb fat: NS DEXA arm fat: NS DEXA leg fat: NS	ND	NS	Cavalcanti et al. [62]
Increase in SAT	28	Rosi versus placebo	3 months	CT thigh (cm^2): rosi: + 2.3 versus pla −0.9, Δ rosi versus pla, 𝑃=.002 CT s.c. abdomen: NS DEXA leg: NS (rosi +50 g versus pla −80g, Δ rosi versus pla 𝑃=.08)	CT: NS	NS	Hadigan et al. [57]
	105	Rosi versus metformin versus rosi + met versus placebo	16 weeks	DEXA leg fat (%): rosi: +4.8, ^∗NS; met: −3.6, ^∗NS; rosi + met: −0.5, ^∗NS; pla: −8.3%, ^∗NS Δ rosi vs pla 𝑃=.03, other groups versus pla, NS DEXA arm fat: NS DEXA limb fat: NS CT  s.c.  abdomen:  NS	CT (%): rosi: 0.0, ^∗NS; met: −0.6,^∗NS; rosi + met: −7.9, ^∗NS; pla: −7.2, ^∗NS Δ rosi versus pla, 𝑃=.08, other groups versus pla, NS	Body mass index ND, body weight (kg): rosi: 0.0, ^∗NS; met: −2.0, ^∗𝑃<.001; rosi + met: −1.5, ^∗𝑃<.01; pla: −0.05, ^∗NS Δ met versus pla, 𝑃=.03; Δ met + rosi versus pla, 𝑃=.06	Mulligan et al. [60]
	130	Pio versus placebo	48 weeks	DEXA limb fat (g): pio: +380 g; pla: +50 g Δ pio versus pla 𝑃=.051 CT s.c. abdomen: NS	CT: NS	Pio: +0.9; pla: +0.3 Δ pio versus pla 𝑃=.07	Slama et al. [66]
	39	Rosi versus metformin	26 weeks	CT s.c. abdomen (cm^2) rosi: +16, ^∗𝑃<.05; met: −11, ^∗𝑃<.05Δ rosi versus met 27cm^2(95% CI, 7 to 46)	CT (cm^2) rosi: −1, ^∗NS; met: −25, ^∗𝑃<.05Δ rosi versus met 24 cm^2 (95% CI, 6 to 51)	Rosi: +0.4, ^∗𝑃<.05; met: −0.4, ^∗𝑃<.05Δ rosi versus met 0.7 (95% CI, 0.5 to 1.6)	van Wijk et al. [58]

* denotes significance within the study group compared to baseline value, Δ denotes comparison of the change between respective study groups.