Role of PPAR in the Control of Torpor through FGF21-NPY Pathway: From Circadian Clock to Seasonal Change in Mammals
Figure 1
Negative transcriptional feedback loop for 24 hrs rhythm generation in manmals. The circadian clock positive transcription factor, CLOCK and BMAL1 transactivates other negative limbs of clock genes such as period (per), cryptochrome (cry) via cis-element E-box in their promoters. These negative components PER and CRY, in turn, suppress the activity of CLOCK/Bmal during about 24 hrs.
