Is PPAR𝛾 a Prospective Player in HIV-1-Associated Bone Disease?

Table 1

PPARγ-regulated genes involved in adiogenesis, glucose uptake, and thermoregulation (↑ positive regulation; ↓ negative regulation).

PPARγ-regulated genes
Gene	Tissue/cell type	Function
CCAT enhancer binding protein α (CEBPα) [7]↑	Adipose/preadipose tissue	Transcription factor. CDK2/4 inhibition-cell cycle arrest
Adipose differentiation related protein (ADRP) [50]↑	Adipose/preadipose tissue	Associated with globule membrane, early marker of adipocyte differentiation
Lipoprotein lipase [49]↑	Vascular endothelium, heart, muscle, adipose	Lipid hydrolysis from lipoproteins
Adiponectin [49]↑	Adipose tissue (secreted)	Fatty acid catabolism
Adipocyte protein 2 (aP2/FABP4) [49]↑	Adipocytes/macrophages	Intercellular lipid transport
Tumour suppressor candidate 5 (TUSC 5) [56]↑	Preadipose/adipose tissue	Associated with entry into the later stages of adipogenesis
Glucose transporters 4 (GLUT) 4 [57]↑	Wide tissue distribution	Insulin stimulated glucose uptake
Uncoupling proteins 1-3 (UCP 1-3) [58]↑	Adipose tissue, skeletal muscle, liver	Thermogenesis/thermoregulation