A Human Hepatocyte-Bearing Mouse: An Animal Model to Predict Drug Metabolism and Effectiveness in Humans
Figure 1
The histological harmonization of h-hepatocytes with m-nonparenchymal cells. uPA/SCID mice were transplanted with h-hepatocytes and allowed to grow until the repopulation of the liver was complete. Then, liver sections were prepared from the h-hepatocyte-chimeric mice. Sections were immunostained with m-specific antibodies for type IV collagen (a); laminin (b); stabillin (c), a marker of liver endothelial cells (a gift from Dr. A. Miyajima, Tokyo University); and BM8 (d), a marker of Kupffer cells. The immunosignals are brown. The arrows in (c) and (d) point to typical immunopositive cells. Bar, .
