MBX-102/JNJ39659100, a Novel Non-TZD Selective Partial PPAR-𝛾 Agonist Lowers Triglyceride Independently of PPAR-𝛼 Activation

Figure 4

Effect of MBX-102 (100 mg/kg) and rosiglitazone (4 mg/kg) on body weight (BW) (a) and white adipose tissue weights (b) after 11 days of treatment of male ZDF rats. For the adipose tissue weight, the values are plotted as mean percentage of vehicle  ±  SEM (∗: 𝑃<.05, ∗∗: 𝑃<.01, ∗∗∗: 𝑃<.001 versus ZDF Vehicle; #: 𝑃<.05, ##: 𝑃<.01 versus MBX-102, (a) 2-way ANOVA and Bonferroni post tests or (b) 1-way ANOVA and Tukey's multiple comparison test).

(a)

(b)