PPAR-𝛾 Agonists and Their Effects on IGF-I Receptor Signaling: Implications for Cancer

Table 1

Mechanisms underlying PPAR-γ pro- and antitumorigenic effects.

Protumorigenic effects	References
(1) Inhibition of PPAR-𝛾 genomic functions by MAPK	[108, 126–143]
(2) PPAR-𝛾 nongenomic functions (MAPK activation, MMP2, and VEGF production)
Antitumorigenic effects	References
(1) PPAR-𝛾 genomic effects	[109, 144–151]
(2) Induction of PTEN expression
(3) Inhibition of p70S6K