PRIC295, a Nuclear Receptor Coactivator, Identified from PPAR𝛼-Interacting Cofactor Complex

Figure 2

PRIC295 structural features. (a) Schematic representation of the PRIC295 protein to indicate the locations of LXXLL motifs in red color and HEAT repeat domains in purple color. (b) Alignment of the orthologous PRIC295 genomic sequences of selected species at the loci of all 10 of the LXXLL motifs contained in the human PRIC295 protein. LXXLLs are numbered L₁ to L₁₀ beginning from the N-terminal region: L₁aa465–469; L₂aa1160–1164; L₃aa 1461–1465; L₄aa1499–1503; L₅aa1596–1600; L₆aa1839–1843; L₇aa1926–1930; L₈aa2045–2049; L₉aa2330–2334; L₁₀aa2594–2598. The model organism to which each sequence corresponds is indicated at the left side of the sequence. The location of conserved proline at—2 of L₂, L₇, and L₁₀ are indicated using an arrow.

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