Coactivators in PPAR-Regulated Gene Expression

Table 1

Some known coactivator and coactivator associated proteins that regulate PPAR function.

Coactivator proteins	Enzyme activity	Function	References
SRC-1/NCoA-1	HAT	Histone acetylation	[51, 52]
SRC-2/TIF2/GRIP1	HAT	Histone acetylation	[53]
SRC3/pCIP/AIB1	HAT	Histone acetylation	[54, 55]
CBP/p300	HAT	Histone acetylation followed by recruitment of p160/SRCs	[56]
MED1/TRAP220/PBP	None	Anchor for Mediator complex	[57, 58]
PGC-1α	None	Recruit coactivator with HAT activities	[59]
PGC-1β/PERC	None	Recruit coactivator with HAT activities	[60]
PRIP/NCoA6	None	Recruit ASC complex	[61, 62]
PRIC285	Helicase	Chromatin remodeling by histone displacement and nucleosomal sliding	[63]
PRIC320/CHD9	Helicase	Chromatin remodeling by histone displacement and nucleosomal sliding	[64]
SWI/SNF	ATPase	ATP dependent mobilization of nucleosome	[65, 66]
BAF60a/SMARCD1	None	Recruit SWI/SNF complex	[67, 68]
BAF60c/SMARCD3	None	Recruit SWI/SNF complex	[69]
Coactivator-associated proteins
PIMT/NCoA6IP	Methyltransferase	Methylation of caps of snRNAs and snoRNAs	[70]
CARM1/PRMT4	Methyltransferase	Potentiate SRCs by methylation of Histone H3	[71]
CoAA	None	RNA splicing	[72]