The Role of Peroxisome Proliferator-Activated Receptor β/δ on the Inflammatory Basis of Metabolic Disease

Figure 2

Potential mechanism of action involved in the reduction of insulin resistance and inflammation in skeletal muscle cells following PPAR𝛽/𝛿 activation by GW501516. ACC-2, acetyl-CoA carboxylase 2; AMPK, AMP-activated protein kinase; CPT-1, carnitine palmitoyltransferase-1; DAG, diacylglycerol; IKK𝛽, IκB kinase 𝛽; IL-6, interleukin 6; IRS-1, Insulin Receptor Substrate 1; NF-κB, Nuclear Factor-κB; PDK-4, pyruvate dehydrogenase kinase 4; PKCθ, protein kinase Cθ.