Induction of Metastatic Gastric Cancer by Peroxisome Proliferator-Activated Receptorδ Activation
Figure 1
PPARδ agonist GW501516 induces gastric tumorigenesis after DMBA treatment. (a) In vivo axial T2-weighted abdominal MR Images showing gastric tumor progression at the indicated time points; , number of days animals were administered the GW501516-supplemented diet. Tumor growth initiated in the forestomach (arrow) at 19 days, rapid tumor growth between 27 and 50 days, and tumor invasion through the stomach (arrow) at 56 days. (b) Gross morphology of tumors at indicated time points. Forestomach (*), gastric tumors () and metastases (arrows) are indicated. Tumor is confined within the stomach at 20 days. Invasion of primary tumor through the stomach () and metastases (arrow) were evident at 56 days, and intraperitoneal metastases along the abdominal wall (white arrows) occurred at 70 days.
