Induction of Metastatic Gastric Cancer by Peroxisome Proliferator-Activated Receptorδ Activation
Figure 3
Differential gene expression in GW501516-treated stomach and gastric tumors. Gene microarray analysis was carried out with pooled RNA samples prepared from either five tissue samples of forestomach from untreated and GW501516 treated mice or six gastric tumors. Heat maps represent unsupervised hierarchical clustering of ≥3-fold changes in signal intensity normalized to untreated forestomach. (a) Heatmap of GW501516-treated versus stomach representing 42 genes. (b) Tumor versus stomach representing 811 genes. (c) qRT-PCR analysis of the relative changes in gene expression in the stomach after GW501516 treatment (GW501516), and in tumors (Tumor). GW501516 treated: array, cross-hatch; qRT-PCR, diagonal; Tumors: array, black; qRT-PCR, white.
