|
| Target genes | Gene expression |
|
| Fatty acid uptake, binding, and activation | |
| Fatty acid transport protein (FATP) | Stimulation |
| Fatty acid translocase (FAT/CD36) | Stimulation |
| Liver cytosolic fatty acid-binding protein (L-FABP) | Stimulation |
| Acyl-CoA synthetase (ACS) | Stimulation |
| Carnitine palmitoyltransferase I and II (CPT-1and CPT-II) | Stimulation |
| Mitochondrial fatty acid β-oxidation | |
| Very long-chain acyl-CoA dehydrogenase (VLCAD) | Stimulation |
| Long chain acyl-CoA dehydrogenase (LCAD) | Stimulation |
| Medium-chain acyl-CoA dehydrogenase (MCAD) | Stimulation |
| Short-chain acyl-CoA dehydrogenase (SCAD) | Stimulation |
| Peroxisomal fatty acid β-oxidation | |
| Acyl-CoA oxidase (ACOX) | Stimulation |
| Bifunctional enzyme (HD) | Stimulation |
| 3-Ketoacyl-CoA thiolase (Thiolase) | Stimulation |
| Hydrolysis of plasma triglycerides | |
| lipoprotein lipase (LPL) | Stimulation |
| Apolipoprotein C-III (Apo C-III) | Inhibition |
| Fatty acid synthesis | |
| Acetyl-CoA carboxylase (ACC) | Inhibition |
| Fatty acid synthase (FAS) | Inhibition |
| HDL metabolism | |
| Apolipoprotein A-I and A-II (ApoA-I and ApoA-II) | Stimulation |
| ATP-binding cassette transporter 1 (ABCA1) | Stimulation |
| Electron transport chain | |
| Uncoupling protein 1, 2, and 3 (UCP1, 2, and 3) | Stimulation |
|
