Coordinate Transcriptomic and Metabolomic Effects of the Insulin Sensitizer Rosiglitazone on Fundamental Metabolic Pathways in Liver, Soleus Muscle, and Adipose Tissue in Diabetic db/db Mice
Figure 1
Expression profiles of key genes involved in liver glucose and lipid metabolism. Differentially expressed genes in db/+ (the white square) as well as 10 (the off-white square), 30 (the grey square), and 100 (the black square) mg/kg RSG-treated db/db mice were measured versus untreated db/db and plotted as the mean (% increase/decrease of db/db control) SEM (). NS; otherwise . (a) Genes related to glucose metabolism: Aldoa, Aldob, aldolase 1A, 2B; Fbp1, fructose bisphosphatase 1; G6pc, glucose-6-phosphatase, catalytic; Gapdh, glyceraldehyde-3-phosphate dehydrogenase; Pdk4, pyruvate dehydrogenase kinase, isoenzyme 4; Pklr, pyruvate kinase liver and red blood cell; Slc2a2, solute carrier family 2 (facilitated glucose transporter), member 2. (b) Genes related to FA transport, FA and TG synthesis, and pentose pathway: Acaca, Acacb, acetyl-Coenzyme A carboxylase alpha, beta; Acly, ATP citrate lyase; Agpat2, Agpat6, 1-acylglycerol-3-phosphate O-acyltransferase 2, 6; Apoc3, apolipoprotein C-III; Cd36, CD36 antigen; Fabp2, fatty acid-binding protein 2, intestinal; Fabp4, fatty acid-binding protein 4, adipocyte; Fasn, fatty acid synthase; Gpd1, glycerol-3-phosphate dehydrogenase 1 (soluble); Lpl, lipoprotein lipase; Mgll, monoglyceride lipase; Pgd, phosphogluconate dehydrogenase; Scd1, stearoyl-Coenzyme A desaturase 1; Taldo1, transaldolase 1; Tkt, transketolase.
