Coordinate Transcriptomic and Metabolomic Effects of the Insulin Sensitizer Rosiglitazone on Fundamental Metabolic Pathways in Liver, Soleus Muscle, and Adipose Tissue in Diabetic db/db Mice

Table 3

Differential expression of the 40 best predictor gene sequences from PLS analysis of combined tissues: liver, IAT, and soleus. x: MatInspector-predicted PPRE.

Tissues	Gene name	Function	Sequence description	PPRE	db/+	RSG 10 MK	RSG 30 MK	RSG 100 MK
					F. C.	F. C.	F. C.	F. C.
S	Cyp4a12a	Fatty acid metabolism	cytochrome P450, family 4, subfamily a, polypeptide 12a		1.72	1.25	1.27	1.46
TA	Dci	Fatty acid metabolism	dodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl-Coenzyme A isomerase)	x	1.51	1.28	1.68	1.85
TA	Mcat	Fatty acid metabolism	malonyl CoA: ACP acyltransferase (mitochondrial)		1.57	1.29	1.54	1.66
TA	Ppargc1b	Fatty acid metabolism	peroxisome proliferative activated receptor, gamma, coactivator 1 beta		1.63	−1.06	1.37	1.83
TA	Ppargc1b	Fatty acid metabolism	peroxisome proliferative activated receptor, gamma, coactivator 1 beta		2.11	1.10	1.67	2.33
TA	Ppargc1b	Fatty acid metabolism	peroxisome proliferative activated receptor, gamma, coactivator 1 beta		1.41	−1.10	1.30	1.80
TA	Dlat	Gluconeogenesis	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	x	1.77	1.49	2.10	2.72
TA	Ldhb	Gluconeogenesis	lactate dehydrogenase B		1.76	1.07	1.36	1.81
TA	Pdhb	Gluconeogenesis	pyruvate dehydrogenase (lipoamide) beta		2.19	1.69	2.49	3.05
TA	Pdhb	Gluconeogenesis	pyruvate dehydrogenase (lipoamide) beta		2.04	1.65	2.32	2.82
L	Pfkfb2	Gluconeogenesis	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	x	−1.16	−1.72	−1.59	−1.56
L	Ppargc1a	Gluconeogenesis	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	x	−1.32	−1.53	−1.61	−1.59
L	Ppargc1a	Gluconeogenesis	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha		−1.64	−1.71	−1.75	−1.75
TA	Atp5h	Mitochondrial respiratory chain	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d	x	1.21	1.07	1.26	1.41
TA	Atp5h	Mitochondrial respiratory chain	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d		1.23	1.06	1.26	1.47
TA	Cox6b1	Mitochondrial respiratory chain	cytochrome c oxidase, subunit VIb polypeptide 1		1.54	1.39	1.82	2.16
TA	Cox6b2	Mitochondrial respiratory chain	cytochrome c oxidase, subunit VIb polypeptide 2		1.35	1.08	1.37	1.59
TA	Cox7a1	Mitochondrial respiratory chain	cytochrome c oxidase, subunit VIIa 1	x	1.37	−1.52	1.45	1.98
TA	Cox7b	Mitochondrial respiratory chain	cytochrome c oxidase, subunit VIIb	x	1.96	1.33	1.87	2.15
TA	Ndufa1	Mitochondrial respiratory chain	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1	x	1.44	1.13	1.42	1.52
TA	Ndufa1	Mitochondrial respiratory chain	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1		1.35	1.09	1.31	1.46
TA	Uqcrb	Mitochondrial respiratory chain	ubiquinol-cytochrome c reductase binding protein	x	1.81	1.40	1.82	2.14
TA	Uqcrfs1	Mitochondrial respiratory chain	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1		1.57	1.24	1.87	2.25
TA	Uqcrh	Mitochondrial respiratory chain	ubiquinol-cytochrome c reductase hinge protein		1.89	1.43	1.81	1.97
TA	Uqcrh	Mitochondrial respiratory chain	ubiquinol-cytochrome c reductase hinge protein		1.65	1.28	1.57	1.83
TA	Fntb	Steroid biosynthesis	farnesyltransferase, CAAX box, beta	x	1.48	1.43	1.55	1.49
L	Hmgcs2	Steroid biosynthesis	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2	x	−1.32	−1.09	−1.28	−1.37
TA	Agpat3	Triglyceride	1-acylglycerol-3-phosphate O-acyltransferase 3	x	1.81	1.31	1.65	2.07
TA	Aco1	Tricarboxylic acid cycle (mit oxidation)	aconitase 1	x	1.77	1.37	1.70	1.94
TA	Aco2	Tricarboxylic acid cycle (mit oxidation)	aconitase 2, mitochondrial	x	1.38	1.18	1.66	1.98
TA	Aldh5a1	Tricarboxylic acid cycle (mit oxidation)	aldhehyde dehydrogenase family 5, subfamily A1	x	1.60	1.33	1.65	1.69
TA	Dlst	Tricarboxylic acid cycle (mit oxidation)	dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)	x	1.43	1.16	1.63	1.83
TA	Fh1	Tricarboxylic acid cycle (mit oxidation)	fumarate hydratase 1	x	1.56	1.28	1.63	1.87
TA	Idh3b	Tricarboxylic acid cycle (mit oxidation)	isocitrate dehydrogenase 3 (NAD+), beta	x	1.49	1.18	1.73	1.91
TA	Idh3g	Tricarboxylic acid cycle (mit oxidation)	isocitrate dehydrogenase 3 (NAD+), gamma	x	1.67	1.18	1.59	1.91
TA	Mdh1	Tricarboxylic acid cycle (mit oxidation)	malate dehydrogenase 1, NAD (soluble)		1.93	1.17	1.91	1.95
TA	Mdh1	Tricarboxylic acid cycle (mit oxidation)	malate dehydrogenase 1, NAD (soluble)		1.63	1.44	2.01	2.17
TA	Sdhb	Tricarboxylic acid cycle (mit oxidation)	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)		1.60	1.21	1.67	1.97
TA	Sdhc	Tricarboxylic acid cycle (mit oxidation)	succinate dehydrogenase complex, subunit C, integral membrane protein	x	1.32	1.10	1.35	1.48
TA	Sdhd	Tricarboxylic acid cycle (mit oxidation)	succinate dehydrogenase complex, subunit D, integral membrane protein	x	1.29	1.11	1.57	1.90