Regulation of Proteome Maintenance Gene Expression by Activators of Peroxisome Proliferator-Activated Receptor α
Figure 5
Expression of chaperone proteins after PPC treatment. (a) Protein expression in the livers of mice treated with different doses of WY. B6C3F1 mice were treated with the indicated concentrations of WY in the diet for 6 days. Protein expression was assessed by Westerns using primary antibodies against the indicated proteins. Blots were quantitated as described in Section 2. (b) Protein expression in livers of wild-type and PPARα-null mice after exposure to DEHP. Proteins were extracted from the livers of wild-type or PPARα-null mice given 7 consecutive doses of DEHP (1000 mg/kg day). There were 3 animals per treatment group. Variability is expressed as standard error of the mean. Means and S.E. () for western data were calculated by Student's -test. The level of significance was set at and significance is indicated with *.
