Gene Expression Profiling in Wild-Type and PPAR-Null Mice Exposed to Perfluorooctane Sulfonate Reveals PPAR-Independent Effects
Table 10
Average fold change for genes related to ribosome biogenesis following a seven-day exposure to Wy-14,64, PFOA1, or PFOS in wild-type and PPAR-null male mice.
WT
Null
Symbol
Gene name
Entrez no.
Wy14,643 50 mg/kg
PFOA 3 mg/kg
PFOS 3 mg/kg
PFOS 10 mg/kg
PFOA 3 mg/kg
PFOS 3 mg/kg
PFOS 10 mg/kg
MRPL12
mitochondrial ribosomal protein L12
56282
−1.16
1.25
1.07
1.14*
−1.16
−1.18
−1.12*
MRPL13
mitochondrial ribosomal protein L13
68537
1.32
1.33
1.12
1.35*
1.01
−1.21
−1.42**
MRPL17
mitochondrial ribosomal protein L17
27397
1.68
1.76
1.10
1.43**
1.13
−1.13
1.09
MRPL23
mitochondrial ribosomal protein L23
19935
−1.14
−1.04
−1.00
1.10
1.09
−1.38
−1.20*
MRPL33
mitochondrial ribosomal protein L33
66845
1.22
1.26
1.07
1.05
1.04
−1.29
−1.28**
MRPS12
mitochondrial ribosomal protein S12
24030
−1.24
1.18
1.05
1.12
1.02
−1.27
−1.15
MRPS18A
mitochondrial ribosomal protein S18A
68565
−1.46
1.34
1.04
1.28*
1.60
−1.19
−1.06
RPL10
ribosomal protein L10
110954
−1.15
−1.21
1.02
1.03
1.07
−1.10
−1.02
RPL10A
ribosomal protein L10A
19896
−1.11
1.10
1.03
1.05
1.00
−1.07
1.01
RPL11
ribosomal protein L11
67025
1.14
1.12
1.10
1.11*
1.15
−1.15
−1.09
RPL12
ribosomal protein L12
269261
1.01
1.37
1.08
1.15*
1.11
−1.08
1.05
RPL13A
ribosomal protein L13a
22121
−1.14
1.03
1.07
1.12*
−1.17
−1.15
−1.10
RPL14
ribosomal protein L14
67115
−1.28
−1.06
1.15
1.23**
−1.13
−1.18
−1.22*
RPL17
ribosomal protein L17
319195
−1.27
1.15
1.03
1.12
−1.52
−1.10
−1.09
RPL18
ribosomal protein L18
19899
−1.11
1.28
1.04
1.07*
1.19
−1.27
−1.09*
RPL18A
ribosomal protein L18a
76808
1.65
−1.37
1.04
1.11*
1.08
−1.15
−1.02
RPL19
ribosomal protein L19
19921
1.22
1.23
1.01
1.05
1.07
−1.11
−1.03
RPL21
ribosomal protein L21
19933
2.00
1.55
1.03
1.09
1.18
−1.20
−1.18
RPL22
ribosomal protein L22
19934
1.17
1.45
1.06
1.29**
1.08
−1.25
−1.14*
RPL23
ribosomal protein L23
65019
−1.07
1.35
1.06
1.06
1.22
−1.24
−1.16
RPL24
ribosomal protein L24
68193
−1.13
1.07
1.06
1.09*
−1.00
−1.19
−1.11*
RPL26
ribosomal protein L26
19941
1.04
1.22
1.03
1.03
1.07
−1.22
−1.18**
RPL27
ribosomal protein L27
19942
1.04
−1.01
1.08
1.38**
1.06
−1.25
−1.40*
RPL27A
ribosomal protein L27a
26451
−1.07
1.07
−1.00
1.17
1.26
−1.17
−1.09
RPL28
ribosomal protein L28
19943
1.29
1.04
1.01
1.11*
1.67
−1.22
−1.10
RPL29
ribosomal protein L29
19944
1.16
−1.30
1.04
1.09
1.08
−1.23
−1.17
RPL3
ribosomal protein L3
27367
−1.00
−1.14
1.01
1.09
−1.01
−1.03
1.06
RPL30
ribosomal protein L30
19946
−1.15
−1.07
1.02
−1.21
−1.04
−1.29
−1.23**
RPL31
ribosomal protein L31
114641
1.11
1.37
1.09
1.05
1.29
−1.18
−1.12*
RPL32
ribosomal protein L32
19951
1.06
1.11
1.02
1.12*
1.08
−1.16
−1.03
RPL34
ribosomal protein L34
68436
−1.26
1.16
−1.07
1.05
−1.04
−1.22
−1.31**
RPL35
ribosomal protein L35
66489
−1.03
1.15
1.13
1.26**
1.04
−1.17
−1.11
RPL36
ribosomal protein L36
54217
−1.07
1.12
1.09
1.23*
1.07
−1.27
−1.20*
RPL37
ribosomal protein L37
67281
−1.16
−1.18
1.04
1.27*
1.17
−1.19
−1.10**
RPL37A
ribosomal protein L37a
19981
−1.15
−1.09
1.03
1.16
−1.12
−1.22
−1.19*
RPL38
ribosomal protein L38
67671
−1.17
1.14
−1.01
1.06
−1.03
−1.18
−1.10
RPL39
ribosomal protein L39
67248
1.04
1.02
1.06
1.13*
1.07
−1.18
−1.16**
RPL4
ribosomal protein L4
67891
1.16
1.43
1.03
1.03
1.32
1.03
1.04
RPL41
ribosomal protein L41
67945
−1.06
1.14
1.05
1.06
−1.13
−1.20
−1.26*
RPL5
ribosomal protein L5
19983
−1.21
1.02
1.24
1.09*
−1.05
−1.05
−1.11
RPL6
ribosomal protein L6
19988
1.01
−1.08
1.00
1.05
1.15
−1.05
1.03
RPL7A
ribosomal protein L7a
27176
−1.02
−1.11
1.01
1.01
−1.02
−1.07
1.01
RPL9
ribosomal protein L9
20005
−1.35
−1.08
1.03
1.07
−1.11
−1.19
−1.12*
RPS10
ribosomal protein S10
67097
−1.02
1.02
1.05
1.07
1.00
−1.17
−1.12*
RPS11
ribosomal protein S11
27207
1.05
−1.74
−1.01
1.11
1.06
−1.24
−1.14*
RPS12
ribosomal protein S12
20042
1.16
1.22
1.11
1.19
1.22
−1.21
−1.12
RPS13
ribosomal protein S13
68052
−1.03
1.10
1.07
1.22*
1.11
−1.27
−1.22*
RPS14
ribosomal protein S14
20044
−1.03
1.19
1.05
1.11*
1.01
−1.17
−1.11**
RPS15A
ribosomal protein S15a
267019
−1.05
1.05
1.02
1.12
1.02
−1.14
−1.20
RPS16
ribosomal protein S16
20055
−1.09
1.05
1.05
1.07
−1.02
−1.12
−1.07
RPS17
ribosomal protein S17
20068
1.00
1.16
1.04
−1.19*
1.01
−1.19
−1.15*
RPS19
ribosomal protein S19
20085
−1.07
1.23
1.08
1.19**
−1.00
−1.14
−1.05
RPS2
ribosomal protein S2
16898
−1.09
1.02
1.04
1.02
−1.16
−1.03
1.04
RPS20
ribosomal protein S20
67427
−1.40
1.21
1.04
1.15
1.25
−1.11
−1.13
RPS21
ribosomal protein S21
66481
1.11
−1.32
1.15
1.38
1.39
−1.32
−1.25**
RPS23
ribosomal protein S23
66475
1.01
1.04
−1.00
1.04
1.09
−1.21
−1.10*
RPS24
ribosomal protein S24
20088
1.58
1.62
1.11
−1.29*
1.75
−1.16
−1.19**
RPS25
ribosomal protein S25
75617
−1.23
1.01
1.09
1.13*
−1.02
−1.30
−1.17*
RPS26
ribosomal protein S26
27370
1.32
1.30
1.04
1.16*
1.14
−1.20
−1.08
RPS27A
ribosomal protein S27a
78294
1.05
−1.05
−1.00
1.02
1.09
−1.08
−1.05
RPS27L
ribosomal protein S27-like
67941
1.72
1.28
1.07
1.14*
1.19
−1.18
−1.17*
RPS28
ribosomal protein S28
54127
−1.19
−1.03
1.03
1.06
−1.05
−1.28
−1.17*
RPS29
ribosomal protein S29
20090
−1.26
−1.05
−1.02
1.01
−1.03
−1.19
−1.20**
RPS3
ribosomal protein S3
27050
−1.04
1.29
1.03
1.20*
−2.88
−1.11
−1.06
RPS3A
ribosomal protein S3A
544977
−1.18
−1.07
1.02
−1.01
−1.05
−1.10
−1.03
RPS5
ribosomal protein S5
20103
−1.16
1.18
1.06
1.09*
−1.02
−1.13
−1.00
RPS6
ribosomal protein S6
20104
−1.20
−1.02
−1.20
1.06
−1.02
−1.14
−1.06*
RPS8
ribosomal protein S8
20116
1.19
−1.05
1.07
1.13*
1.04
−1.29
−1.13
RPS9
ribosomal protein S9
76846
−1.39
1.30
1.05
1.07
1.05
−1.08
−1.04
1From Rosen et al. (2008), *Significantly different than control (),
**Significantly different from control ().