Gene Expression Profiling in Wild-Type and PPAR𝛼-Null Mice Exposed to Perfluorooctane Sulfonate Reveals PPAR𝛼-Independent Effects

Table 3

Average fold change for genes related to lipid metabolism in wild-type and PPAR$\alpha$-null male mice following a seven-day exposure to Wy-14,64$3^1$, PFOA¹, or PFOS.

				WT				Null
Symbol	Gene name	Entrez no.	Wy14,643 50 mg/kg	PFOA 3 mg/kg	PFOS 3 mg/kg	PFOS 10 mg/kg	PFOA 3 mg/kg	PFOS 3 mg/kg	PFOS 10 mg/kg
ACAA1	acetyl-CoA; acyltransferase 1	113868	1.89	2.92	1.61	2.10**	1.22	1.37	1.53*
ACAA1B	acetyl-CoA; acyltransferase 1B	235674	2.38	2.70	1.49	1.40**	3.00	1.09	1.19*
ACAD10	acyl-CoA dehydrogenase,; member 10	71985	1.51	2.39	−1.18	1.38**	−1.01	1.05	1.20*
ACADL	acyl-CoA dehydrogenase,; long chain	11363	3.03	2.86	1.40	1.68**	2.50	1.34	1.59**
ACADM	acyl-CoA dehydrogenase,; C-4 to C-12	11364	1.70	1.30	1.21	1.31**	1.06	1.11	1.10
ACADS	acyl-CoA dehydrogenase,; C-2 to C-3	66885	1.03	1.52	1.22	1.31*	−1.13	−1.12	−1.08
ACADSB	acyl-CoA dehydrogenase,; short/branched	66885	−1.56	−1.64	−1.04	−1.39**	−1.26	1.00	−1.23
ACADVL	acyl-CoA dehydrogenase,; very long chain	11370	1.92	1.80	1.44	1.49**	1.16	1.04	1.12
ACAT1	acetyl-CoA; acetyltransferase 1	101446	−1.01	1.10	1.45	1.36*	−1.55	−1.05	−1.17
ACAT2	acetyl-CoA; acetyltransferase 2	110460	2.59	1.68	1.14	1.34*	1.26	1.58	1.69**
ACOT1	acyl-CoA thioesterase 1	26897	19.48	73.06	3.27	6.82**	2.95	1.53	2.02
ACOT3	acyl-CoA thioesterase 3	171281	2.55	32.83	2.42	6.41**	−1.59	1.46	1.86
ACOT2	acyl-CoA thioesterase 2	171210	3.83	19.29	1.91	7.32**	1.78	1.25	1.52
ACOX1	acyl-CoA oxidase 1	11430	5.65	7.17	1.23	1.49**	1.51	1.30	1.29**
ACSL1	acyl-CoA synthetase long-; chain member1	14081	1.34	2.36	1.28	1.36**	1.01	1.31	1.30
ACSL3	acyl-CoA synthetase long-; chain member3	74205	2.25	1.90	1.28	1.69**	1.11	1.77	1.63
ACSL4	acyl-CoA synthetase long-; chain member4	50790	1.95	2.00	1.03	1.42*	1.51	1.34	1.29
ACSL5	acyl-CoA synthetase long-; chain member5	433256	3.06	2.76	1.24	1.31**	1.38	1.23	1.28
ALDH1A1	aldehyde dehydrogenase 1,; member A1	11668	1.56	1.59	1.07	1.12**	1.22	1.16	1.17
ALDH1A7	aldehyde dehydrogenase 1, A7	26358	1.83	1.86	1.12	1.24*	1.55	1.26	1.35
ALDH3A2	aldehyde dehydrogenase 3,; member A2	11671	3.65	7.72	2.10	3.80**	2.30	1.73	2.20**
ALDH9A1	aldehyde dehydrogenase 9,; member A1	56752	1.80	1.91	1.27	1.50**	1.21	1.05	1.11*
CPT1B	carnitine palmitoyltransferase; 1B (muscle)	12896	2.29	1.50	1.23	2.69**	−1.00	1.13	1.11
CPT2	carnitine palmitoyltransferase II	12896	1.33	2.54	1.58	2.03**	1.44	1.15	1.34
CYP4A14	cytochrome P450, 4, a,; polypeptide 14	13119	75.38	103.48	11.26	12.28**	12.75	−1.09	2.22
DCI	dodecenoyl-CoA; delta isomerase	13177	2.91	4.55	1.90	2.38**	1.99	1.04	1.38*
ECH1	enoyl CoA hydratase 1,; peroxisomal	51798	3.27	5.23	1.93	2.49**	2.10	1.16	1.39
EHHADH	enoyl-CoA, hydratase	74147	27.89	22.11	2.37	4.34**	1.37	1.32	1.52*
FABP1	fatty acid binding protein 1, liver	14080	−1.27	1.02	1.11	1.24**	1.25	−1.09	−1.23
HADHA	Trifunctional protein, alpha unit	97212	2.13	2.95	1.37	1.65**	1.01	1.06	1.02
HADHB	Trifunctional protein, beta unit	231086	2.33	3.43	1.37	1.60**	1.08	−1.15	−1.28*
HSD17B4	hydroxysteroid (17-beta); dehydrogenase4	15488	2.03	2.56	1.34	1.45**	−1.13	1.12	1.20*
SLC27A1	solute carrier 27, member 1	26457	9.14	8.22	−1.02	1.14*	−1.57	1.04	1.04
SLC27A2	solute carrier 27,; member 2	26458	1.48	1.80	1.19	1.16**	1.33	1.10	1.05
SLC27A4	solute carrier 27,; member 4	26569	1.87	1.91	1.04	1.31**	−1.03	1.09	1.07

¹From Rosen et al. (2008),
*Significantly different than control ($P\le .03$),
**Significantly different than control ($P\le .0025$)