Gene Expression Profiling in Wild-Type and PPAR𝛼-Null Mice Exposed to Perfluorooctane Sulfonate Reveals PPAR𝛼-Independent Effects

Table 6

Average fold change for genes related to the inflammatory response in wild-type and PPAR$\alpha$-null male mice following a seven-day exposure to Wy-14,64$3^1$, PFOA¹, or PFOS.

					WT			Null
Symbol	Gene name	Entrez no.	Wy14,643 50 mg/kg	PFOA 3 mg/kg	PFOS 3 mg/kg	PFOS 10 mg/kg	PFOA 3 mg/kg	PFOS 3 mg/kg	PFOS 10 mg/kg
APCS	amyloid P component,; serum	20219	−1.50	−2.33	−1.23	−1.28	−1.19	1.41	1.13
C1QA	complement component; 1QA	12259	−1.75	−1.40	−1.13	−1.17	−1.31	−1.24	−1.34**
C1R	complement component 1r	50909	−2.67	−1.78	−1.15	−1.23*	−1.22	1.16	−1.17*
C1S	complement component 1s	317677	−3.73	−2.53	−1.14	−1.62**	−1.52	1.06	−1.11
C2	complement component 2	12263	−2.56	−1.91	−1.37	−1.32*	−1.18	1.10	1.11
C3	complement component 3	12266	−1.41	−1.41	−1.04	−1.04	−1.22	1.13	1.08*
C4B	complement component 4B	12268	−2.35	−2.15	−1.08	−1.28	−1.91	1.15	−1.13
C4BP	complement component; 4 binding prot	12269	−1.86	−1.82	−1.11	−1.19	1.02	1.39	1.13
C6	complement component 6	12274	−2.66	−1.27	−1.35	−1.08	1.90	1.12	1.06
C8A	complement; component 8, alpha	230558	−3.62	−1.94	−1.17	−1.31*	−1.17	1.19	1.04
C8B	complement; component 8, beta	110382	−5.25	−2.99	−1.20	−1.60**	−1.12	1.11	1.02
C8G	complement; component 8, gamma	69379	−1.59	−1.35	−1.05	−1.17*	−1.34	−1.10	−1.17**
C9	complement; component 9	12279	−2.12	−2.64	−1.35	−1.58**	−1.46	1.08	−1.19*
CFB	complement; factor B	14962	−1.81	−1.77	−1.07	−1.26	−1.39	1.07	−1.11
CFH	complement; factor H	12628	−2.39	−2.30	−1.19	−1.62	−1.76	1.45	−1.35
CFI	complement; factor I	12630	−1.63	−1.77	−1.06	−1.15	−1.06	1.12	1.04
CRP	C−reactive; protein	12944	−1.33	−1.39	−1.01	−1.15*	1.32	1.14	1.13
CTSC	cathepsin C	13032	−1.56	−2.52	1.01	−1.36	−1.96	1.04	−1.35
F10	coagulation; factor X	14058	−1.62	−1.42	−1.09	−1.13	−1.00	1.07	−1.07
F11	coagulation; factor XI	109821	−2.17	−2.68	−1.41	−2.08**	−1.08	−1.08	−1.34*
F12	coagulation; factor XII	58992	−1.22	−1.35	−1.05	−1.14	−1.21	−1.07	−1.12*
F13B	coagulation; factor XIII,; B polypeptide	14060	−1.41	−1.54	−1.11	−1.22**	1.02	1.02	−1.12
F2	coagulation; factor II (thrombin)	14061	−1.19	−1.20	−1.02	−1.13*	−1.10	1.02	−1.02
F5	coagulation; factor V	14067	−1.78	−1.53	−1.09	−1.44*	−1.41	1.08	−1.34*
F7	coagulation; factor VII	14068	−2.68	−2.15	−1.09	−1.46**	−1.23	1.03	−1.03
F9	coagulation; factor IX	14071	−1.42	−1.43	−1.02	−1.39*	−1.33	1.07	−1.19
FGA	fibrinogen; alpha chain	14161	−1.27	−1.75	1.00	−1.12	−1.07	1.05	−1.07
FGB	fibrinogen; beta chain	110135	−1.32	−1.97	1.03	−1.15	−1.25	1.08	−1.07
FGG	fibrinogen gamma; chain	99571	−1.14	−1.68	1.02	−1.15*	−1.08	1.04	−1.06
KLKB1	kallikrein B,; plasma (Fletcher; factor) 1	16621	−1.58	−1.76	−1.09	−1.39*	−1.05	−1.03	−1.18*
LUM	lumican	17022	−1.34	−1.27	1.02	−1.20*	−1.66	1.03	−1.27
MASP1	Mannan-; binding lectin1	17174	−1.23	−1.62	−1.19	−1.18*	1.11	1.18	1.17*
MBL2	Mannose-binding; lectin 2	17195	−1.77	−2.18	−1.12	−1.23*	−1.36	−1.20	−1.28**
ORM2	orosomucoid 2	18405	−1.96	−2.04	−1.26	−1.21	−1.16	1.30	1.05
PROC	protein C	19123	−1.49	−1.50	−1.02	−1.13*	−1.09	−1.01	−1.09*
SAA1	serum amyloid; A1	20209	−3.71	−3.98	−2.75	1.04	−2.76	6.51	2.55
SAA2	serum amyloid; A2	20210	−1.75	−1.30	−1.79	−1.29	3.05	1.44	1.22
SAA4	serum amyloid; A4, constitutive	20211	−2.19	−1.45	−1.06	−1.27	−1.02	1.47	−1.05
SERPINA1	serpin peptidase; inhibitor, clade A1	20701	−3.43	−2.07	−1.03	−1.05**	−1.16	1.11	−1.33
SERPINC1	serpin peptidase; inhibitor, clade C1	11905	−1.19	−1.21	−1.03	−1.08*	−1.02	−1.04	−1.06*
SERPIND1	serpin peptidase; inhibitor, clade D1	15160	−1.62	−1.70	−1.08	−1.25**	−1.05	1.09	1.05
SERPINE1	serpin peptidase; inhibitor, clade E1	18787	1.44	9.75	1.03	1.85**	2.95	1.03	1.26*
SERPINF2	serpin peptidase; inhibitor, clade F2	18816	−1.15	−1.87	1.01	−1.13*	1.02	1.12	1.05
SERPING1	serpin peptidase; inhibitor, clade G1	12258	−1.23	−1.37	−1.12	−1.13	−1.07	1.12	1.02
VWF	von Willebrand; factor	22371	1.06	1.12	−1.25	1.07	−1.51	1.22	1.14

¹From Rosen et al. [1],
*Significantly different than control ($P\le .03$),
**Significantly different than control ($P\le .0025$).