PPAR Research

Research Article

Gene Expression Profiling in Wild-Type and PPAR 𝛼 -Null Mice Exposed to Perfluorooctane Sulfonate Reveals PPAR 𝛼 -Independent Effects

Table 9

Average fold change for genes related to oxidative phosphorylation/electron transport in wild-type and PPARα-null male mice following a seven-day exposure to Wy-14,6431, PFOA1, or PFOS.
WTNull
SymbolGene nameEntrez no.Wy14,643 50 mg/kgPFOA 3 mg/kgPFOS 3 mg/kgPFOS 10 mg/kgPFOA 3 mg/kgPFOS 3 mg/kgPFOS 10 mg/kg
ATP5DATP synthase H+
transporting,
F1delta		660431.031.101.041.09−1.17−1.22−1.13*
ATP5EATP synthase H+
transporting,
F1epsilon		67126−1.101.21−1.001.03−1.17−1.32−1.38**
ATP5G2ATP synthase H+
transporting,
F0, C2		67942−1.09−1.031.10−1.10−1.10−1.33−1.26**
ATP5G3ATP synthase H+
transporting,
F0, C3		2280331.621.48−1.011.05−1.10−1.12−1.10**
ATP5HATP synthase H+
transporting,
F0, D		716791.181.101.051.06−1.01−1.30−1.38**
ATP5IATP synthase H+
transporting,
F0, E		11958−1.01−1.45−1.031.101.17−1.38−1.50**
ATP5JATP synthase H+
transporting,
F0, F6		11957−1.201.44−1.04−1.07−1.14−1.25−1.35**
ATP5J2ATP synthase H+
transporting,F0, F2		574232.38−1.56−1.05−1.091.03−1.29−1.35**
ATP5LATP synthase H+ transporting,
F0, G		274251.581.21−1.021.00−1.05−1.33−1.30**
ATP5OATP synthase H+
transporting,
F1, O		280801.121.161.061.22−1.03−1.33−1.31**
ATP6V0BATPase, H+
transporting,
V0 unit b		114143−1.37−1.251.03−1.091.05−1.22−1.20**
ATP6V1FATPase, H+
transporting,
V1 unit F		66144−1.181.231.001.051.01−1.33−1.28**
COX4I1cytochrome c
oxidase unit
IV isoform 1		128571.141.151.021.03−1.15−1.19−1.16**
COX5Acytochrome c
oxidase unit Va		128581.251.12−1.021.09−1.13−1.26−1.33**
COX5Bcytochrome c
oxidase unit Vb		128591.191.331.091.08−1.27−1.27−1.35**
COX6B1cytochrome c
oxidase unit VIb1		1103231.321.39−1.011.10*−1.12−1.25−1.19*
COX6Ccytochrome c
oxidase unit VIc		128641.62−1.231.03−1.051.21−1.22−1.25**
COX7A2cytochrome c
oxidase unit VIIa 2		12866−1.68−1.08−1.04−1.04−1.57−1.39−1.37**
COX7Ccytochrome c
oxidase unit VIIc		128671.221.32−1.03−1.28*−1.05−1.23−1.19**
COX8Acytochrome c
oxidase unit 8A		128681.341.341.021.041.07−1.23−1.13*
NDUFA1NADH dehydrogenase 1
alpha1		54405−1.191.13−1.03−1.11−1.25−1.31−1.49**
NDUFA2NADH dehydrogenase 1
alpha 2		179911.061.181.041.04−1.06−1.26−1.33**
NDUFA3NADH dehydrogenase 1
alpha 3		660911.601.601.061.16*−1.06−1.37−1.30**
NDUFA4NADH dehydrogenase 1
alpha 4		179921.022.46−1.001.013.16−1.12−1.11**
NDUFA5NADH dehydrogenase 1
alpha 5		682021.411.261.101.11−1.07−1.55−1.73**
NDUFA6NADH dehydrogenase 1
alpha 6		671301.101.061.02−1.04−1.02−1.34−1.29**
NDUFA7NADH dehydrogenase 1
alpha 7		66416−1.14−1.011.091.12−1.17−1.45−1.38**
NDUFA8NADH dehydrogenase 1
alpha 8		683751.141.331.001.091.05−1.29−1.18*
NDUFA12NADH dehydrogenase 1
alpha12		664141.471.16−1.031.061.06−1.51−1.40**
NDUFA13NADH dehydrogenase 1
alpha13		67184−1.12−1.16−1.03−1.03−1.08−1.26−1.28**
NDUFA9NADH dehydrogenase 1
alpha 9		661081.181.071.02−1.01−1.09−1.20−1.19**
NDUFAB1NADH dehydrogenase 1,
alpha/beta 1		703161.561.191.051.23*−1.07−1.31−1.44*
NDUFB2NADH dehydrogenase 1
beta 2		68198−2.31−3.321.041.111.49−1.31−1.35**
NDUFB3NADH dehydrogenase 1
beta 3		664951.551.931.091.191.05−1.41−1.32**
NDUFB4NADH dehydrogenase 1
beta 4		68194−1.031.17−1.011.06−1.13−1.45−1.46**
NDUFB5NADH dehydrogenase 1
beta 5		660461.211.131.081.031.05−1.28−1.41**
NDUFB6NADH dehydrogenase 1
beta 6,		2300751.32−1.031.041.19−1.02−1.38−1.36**
NDUFB7NADH dehydrogenase 1
beta 7,		669161.021.141.041.11−1.11−1.40−1.29**
NDUFB9NADH dehydrogenase 1
beta 9,		662181.191.011.051.01−1.08−1.22−1.25**
NDUFB11NADH dehydrogenase 1
beta 11		104130−1.291.051.051.06−1.00−1.26−1.23**
NDUFC1NADH dehydrogenase 1
unknown 1		66377−1.281.841.071.21*1.17−1.28−1.37**
NDUFC2NADH dehydrogenase 1
unknown, 2		68197−1.021.131.061.06−1.13−1.37−1.33**
NDUFS4NADH dehydrogenase
Fe-S protein 4		179931.511.211.12−1.121.07−1.41−1.40**
NDUFS5NADH dehydrogenase
Fe-S protein 5		5951361.161.13−1.011.081.02−1.37−1.44**
NDUFS7NADH dehydrogenase
Fe-S protein 7		754061.091.401.091.13*1.07−1.28−1.15
NDUFS6NADH dehydrogenase
Fe-S protein 6		407785−1.321.06−1.011.02−1.14−1.30−1.32**
NDUFV2NADH dehydrogenase
flavoprotein 2		729001.381.091.061.07−1.02−1.24−1.24**
NDUFV3NADH dehydrogenase
flavoprotein 3,		783301.121.16−1.03−1.01−1.14−1.35−1.39**
UCRCubiquinol-cytochrome c
reductase		661521.581.261.101.271.07−1.40−1.27**
UHRF1BP1UHRF1 binding
protein 1		224648−1.031.36−1.081.061.151.231.15**
UQCRubiquinol-cytochrome
c reductase		665941.261.401.041.14*1.09−1.28−1.19*
UQCRC2ubiquinol-cytochrome
c reductase CP II		670031.091.171.071.13−1.04−1.11−1.27*
UQCRQubiquinol-cytochrome
c reductase 3 unit 7		222721.011.081.071.12*−1.07−1.18−1.21**
1From Rosen et al. [1], *Significantly different than control (P≤.03),**Significantly different than control (P≤.0025).