Review Article

Homocysteine and Hypertension in Diabetes: Does PPARγ Have a Regulatory Role?

Figure 2

Glomerular hypertrophy and collapse in diabetes were ameliorated by ciglitazone. Histological kidney section were stained with Masson-Trichrome stain and visualized under dissecting microscope. Note that glomerular hypertrophy was observed at one week of alloxan (a single dose of 65 mg/kg body wt intraperitoneally) treatment. At 10 weeks glomerulus was collapsed. Ciglitazone treatment after 10 weeks of alloxan treatment reversed glomerular deformation towards normal (magnification, x200).
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