Anticancer Role of PPARγ Agonists in Hematological Malignancies Found in the Vasculature, Marrow, and Eyes

Figure 5

PPAR $\gamma$ is broadly expressed in the eye providing a pharmacological target for treating ocular angiogenesis. PPAR$\gamma$ expression is found in the retina including RPE cells, REC, pericytes [287], and ganglion cells. In the cornea, PPAR$\gamma$ is most prominently localized in the epithelial and endothelial layers. Excessive angiogenesis is a pathological hallmark of a number of eye diseases, and anti-VEGF/VEGFR strategies are used therapeutically to treat ocular neovascularization. Manifestations of hematological malignancies in the eye have been documented for leukemia, lymphoma, and multiple myeloma. The potential benefits of PPAR$\gamma$ agonist therapy to inhibit tumor-associated angiogenesis could also be applied to treatment of neovascular eye diseases.