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1. T. Hla and K. Neilson, “Human cyclooxygenase-2 cDNA,” Proceedings of the National Academy of Sciences of the United States of America, vol. 89, no. 16, pp. 7384–7388, 1992. View at Publisher · View at Google Scholar
2. A. J. Dannenberg, N. K. Altorki, J. O. Boyle, D. T. Lin, and K. Subbaramaiah, “Inhibition of cyclooxygenase-2: an approach to preventing cancer of the upper aerodigestive tract,” Annals of the New York Academy of Sciences, vol. 952, pp. 109–115, 2001.
3. M. J. Thun, S. J. Henley, and T. Gansler, “Inflammation and cancer: an epidemiological perspective,” Novartis Foundation Symposium, vol. 256, pp. 6–21, 2004.
4. C. Bucher, P. Jordan, V. Nickeleit, J. Torhorst, and M. J. Mihatsch, “Relative risk of malignant tumors in analgesic abusers. Effects of long-term intake of aspirin,” Clinical Nephrology, vol. 51, no. 2, pp. 67–72, 1999.
5. M. Oshima, N. Murai, S. Kargman, et al., “Chemoprevention of intestinal polyposis in the Apcdelta716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitor,” Cancer Research, vol. 61, no. 4, pp. 1733–1740, 2001.
6. C. Denkert, M. Köbel, S. Berger, et al., “Expression of cyclooxygenase 2 in human malignant melanoma,” Cancer Research, vol. 61, no. 1, pp. 303–308, 2001.
7. C. Lee, J. A. Ramirez, J. Guitart, and L. K. Diaz, “Expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor gamma during malignant melanoma progression,” Journal of Cutaneous Pathology, vol. 35, no. 11, pp. 989–994, 2008. View at Publisher · View at Google Scholar · View at PubMed
8. S. Y. Buckman, A. Gresham, P. Hale, et al., “COX-2 expression is induced by UVB exposure in human skin: implications for the development of skin cancer,” Carcinogenesis, vol. 19, no. 5, pp. 723–729, 1998.
9. T. Nijsten, E. Geluyckens, C. Colpaert, and J. Lambert, “Peroxisome proliferator-activated receptors in squamous cell carcinoma and its precursors,” Journal of Cutaneous Pathology, vol. 32, no. 5, pp. 340–347, 2005. View at Publisher · View at Google Scholar · View at PubMed
10. H. P. Koeffler, “Peroxisome proliferator-activated receptor gamma and cancers,” Clinical Cancer Research, vol. 9, no. 1, pp. 1–9, 2003.
11. E. Mueller, M. Smith, P. Sarraf, et al., “Effects of ligand activation of peroxisome proliferator-activated receptor $\gamma$ in human prostate cancer,” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 20, pp. 10990–10995, 2000. View at Publisher · View at Google Scholar · View at PubMed
12. V. Subbarayan, A. L. Sabichi, J. Kim, et al., “Differential peroxisome proliferator-activated receptor-$\gamma$ isoform expression and agonist effects in normal and malignant prostate cells,” Cancer Epidemiology, Biomarkers & Prevention, vol. 13, no. 11, pp. 1710–1716, 2004.
13. E. Mueller, P. Sarraf, P. Tontonoz, et al., “Terminal differentiation of human breast cancer through PPAR$\gamma$,” Molecular Cell, vol. 1, no. 3, pp. 465–470, 1998. View at Publisher · View at Google Scholar
14. G. Y. Zhang, N. Ahmed, C. Riley, et al., “Enhanced expression of peroxisome proliferator-activated receptor gamma in epithelial ovarian carcinoma,” British Journal of Cancer, vol. 92, no. 1, pp. 113–119, 2005. View at Publisher · View at Google Scholar · View at PubMed
15. S. Stadlmann, U. Gueth, E. Wight, L. A. Kunz-Schughart, A. Hartmann, and G. Singer, “Expression of peroxisome proliferator activated receptor $\gamma$ and cyclo-oxygenase 2 in primary and recurrent ovarian carcinoma,” Journal of Clinical Pathology, vol. 60, no. 3, pp. 307–310, 2007. View at Publisher · View at Google Scholar · View at PubMed
16. S. Hazra, K. A. Peebles, S. Sharma, J. T. Mao, and S. M. Dubinett, “The role of PPAR$\gamma$ in the cyclooxygenase pathway in lung cancer,” PPAR Research, vol. 2008, Article ID 790568, 7 pages, 2008. View at Publisher · View at Google Scholar · View at PubMed
17. R. N. DuBois, R. Gupta, J. Brockman, B. S. Reddy, S. L. Krakow, and M. A. Lazar, “The nuclear eicosanoid receptor, PPAR$\gamma$, is aberrantly expressed in colonic cancers,” Carcinogenesis, vol. 19, no. 1, pp. 49–53, 1998. View at Publisher · View at Google Scholar
18. C. Grommes, G. E. Landreth, and M. T. Heneka, “Antineoplastic effects of peroxisome proliferator-activated receptor $\gamma$ agonists,” The Lancet Oncology, vol. 5, no. 7, pp. 419–429, 2004. View at Publisher · View at Google Scholar · View at PubMed
19. W. Placha, D. Gil, A. Dembinska-Kiec, and P. Laidler, “The effect of PPAR$\gamma$ ligands on the proliferation and apoptosis of human melanoma cells,” Melanoma Research, vol. 13, no. 5, pp. 447–456, 2003. View at Publisher · View at Google Scholar
20. C. Freudlsperger, I. Moll, U. Schumacher, and A. Thies, “Anti-proliferative effect of peroxisome proliferator-activated receptor gamma agonists on human malignant melanoma cells in vitro,” Anti-Cancer Drugs, vol. 17, no. 3, pp. 325–332, 2006. View at Publisher · View at Google Scholar
21. C. Hafner, A. Reichle, and T. Vogt, “New indications for established drugs: combined tumor-stroma-targeted cancer therapy with PPAR$\gamma$ agonists, COX-2 inhibitors, mTOR antagonists and metronomic chemotherapy,” Current Cancer Drug Targets, vol. 5, no. 6, pp. 393–419, 2005. View at Publisher · View at Google Scholar
22. A. Reichle, T. Vogt, B. Coras, et al., “Targeted combined anti-inflammatory and angiostatic therapy in advanced melanoma: a randomized phase II trial,” Melanoma Research, vol. 17, no. 6, pp. 360–364, 2007. View at Publisher · View at Google Scholar · View at PubMed
23. A. Reichle, K. Bross, T. Vogt, et al., “Pioglitazone and rofecoxib combined with angiostatically scheduled trofosfamide in the treatment of far-advanced melanoma and soft tissue sarcoma,” Cancer, vol. 101, no. 10, pp. 2247–2256, 2004. View at Publisher · View at Google Scholar · View at PubMed
24. R. Simon, A. Nocito, T. Hübscher, et al., “Patterns of her-2/neu amplification and overexpression in primary and metastatic breast cancer,” Journal of the National Cancer Institute, vol. 93, no. 15, pp. 1141–1146, 2001. View at Publisher · View at Google Scholar
25. L. Bubendorf, A. Nocito, H. Moch, and G. Sauter, “Tissue microarray (TMA) technology: miniaturized pathology archives for high-throughput in situ studies,” The Journal of Pathology, vol. 195, no. 1, pp. 72–79, 2001. View at Publisher · View at Google Scholar · View at PubMed
26. P. J. Wild, S. Meyer, F. Bataille, et al., “Tissue microarray analysis of methylthioadenosine phosphorylase protein expression in melanocytic skin tumors,” Archives of Dermatology, vol. 142, no. 4, pp. 471–476, 2006. View at Publisher · View at Google Scholar · View at PubMed
27. A. Nocito, L. Bubendorf, E. M. Tinner, et al., “Microarrays of bladder cancer tissue are highly representative of proliferation index and histological grade,” The Journal of Pathology, vol. 194, no. 3, pp. 349–357, 2001.
28. D. Hanahan, G. Bergers, and E. Bergsland, “Less is, more, regularly: metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice,” The Journal of Clinical Investigation, vol. 105, no. 8, pp. 1045–1047, 2000. View at Publisher · View at Google Scholar · View at PubMed
29. V. Hofmeister, D. Schrama, and J. C. Becker, “Anti-cancer therapies targeting the tumor stroma,” Cancer Immunology, Immunotherapy, vol. 57, no. 1, pp. 1–17, 2008. View at Publisher · View at Google Scholar · View at PubMed
30. G. P. Vandoros, P. A. Konstantinopoulos, G. Sotiropoulou-Bonikou, et al., “PPAR-gamma is expressed and NF-KB pathway is activated and correlates positively with COX-2 expression in stromal myofibroblasts surrounding colon adenocarcinomas,” Journal of Cancer Research and Clinical Oncology, vol. 132, no. 2, pp. 76–84, 2006. View at Publisher · View at Google Scholar · View at PubMed
31. H. Inoue, T. Tanabe, and K. Umesono, “Feedback control of cyclooxygenase-2 expression through PPAR$\gamma$,” The Journal of Biological Chemistry, vol. 275, no. 36, pp. 28028–28032, 2000. View at Publisher · View at Google Scholar · View at PubMed
32. H. Ikawa, H. Kameda, H. Kamitani, et al., “Effect of PPAR activators on cytokine-stimulated cyclooxygenase-2 expression in human colorectal carcinoma cells,” Experimental Cell Research, vol. 267, no. 1, pp. 73–80, 2001.