Cyclooxygenase 2 (COX2) and Peroxisome Proliferator-Activated Receptor Gamma (PPARG) Are Stage-Dependent Prognostic Markers of Malignant Melanoma

Table 3

Univariate analysis of factors regarding tumor progression and death.

Variable  Categorization	Tumor progression			Death
	$n^{\text{a}}$	events	$P^{\text{b}}$	$n^{\text{a}}$	events	$P^{\text{b}}$
Age at diagnosis
$\le$60 years	48	25	0.7	48	7	0.6
$>$60 years	40	18		40	7
Gender
female	39	15	0.06	39	5	0.4
male	49	28		49	9
Clark ${\text{level}}^{(\text{c})}$
II	5	0	0.4	5	0	0.3
III	15	8		15	2
IV	54	28		54	8
V	13	7		13	4
Tumor thickness
$\le$2.0 mm	38	14	0.03	38	4	0.2
$>$2.0 mm	50	29		50	10
Ki67 labeling index
$<$5%	33	17	0.7	33	7	0.9
$\ge$5%	36	16		36	7
Cytoplasmic COX2 IHC
score 0	12	2	0.03	12	0	0.1
score 1+-3+	72	39		72	14
Nuclear PPARG IHC
score 0	61	28	0.2	61	11	0.6
score 1+-3+	17	10		17	2

${}^{\text{a}}\text{Only}$ initial and unifocal malignant melanomas were included; ${}^{\text{b}}\text{L}$og rank test (two-sided), bold face representing significant data; ${}^{\text{c}}\text{According}$ to UICC: TNM Classification of Malignant Tumours. 6th edn (2002) Sobin LH, Wittekind CH (eds.) Wiley, New York.