Cardiomyocyte-Restricted Deletion of PPARβ/δ in PPARα-Null Mice Causes Impaired Mitochondrial Biogenesis and Defense, but No Further Depression of Myocardial Fatty Acid Oxidation
Table 2
Echocardiography measurement in mice ~two weeks after the end of tamoxifen treatment.
Parameters
TMCM
Pa
TMPD
TMPDPA
IVS;d (mm)
0.77 ± 0.02
0.81 ± 0.04
0.95 ± 0.06*
0.96 ± 0.02*
IVS;s (mm)
1.29 ± 0.06
1.16 ± 0.08
1.30 ± 0.05
1.12 ± 0.05
LVID;d (mm)
3.65 ± 0.06
3.85 ± 0.11
3.91 ± 0.11
3.65 ± 0.09
LVID;s (mm)
2.2 ± 0.09
2.12 ± 0.09
2.54 ± 0.11*
2.62 ± 0.09*
LVPW;d (mm)
0.69 ± 0.03
0.67 ± 0.05
0.76 ± 0.04
0.61 ± 0.02
LVPW;s (mm)
1.13 ± 0.04
0.99 ± 0.06
1.13 ± 0.06
1.05 ± 0.02
Ejection Fraction (%)
71.5 ± 1.5
73.66 ± 1.68
64.71 ± 2.41*
60.57 ± 2.31*
Fractional Shortening (%)
40.1 ± 2
41.9 ± 1.39
35.01 ± 1.84*
31.93 ± 1.59*
MV Decel rate (mm/s2)
−38144 ± 1666
−30433 ± 2693
−23192 ± 828*
−19992 ± 2873*
HR (Beat/Min)
414 ± 7
406 ± 13
417 ± 25
390 ± 14
LV mass/BW
3.29 ± 0.13
3.50 ± 0.1
4.05 ± 0.2*
4.05 ± 0.12*
IVS;d and IVS;s: interventricular septum (diastole and systole); LVID;d and LVID;s: left ventricular internal diameter (diastole and systole); LVPW;d and LVPW;s: left ventricular posterior wall (diastole and systole); EF%: ejection fraction; FS%: fractional shortening. MV decal rate: mitral valve deceleration rate; HR: heart rate, LV mass/BW: ratio of left ventricular mass to body weight. * versus TMCM .
