Fenofibrate Inhibited the Differentiation of T Helper 17 Cells In Vitro

Figure 4

Fenofibrate reduced IL-21 production in the Th17 differentiation system. Total T cells were isolated from mouse spleens and induced differentiation to IL-17⁺ cells with 10 ng/mL TGF-β, 40 ng/mL IL-6, and fenofibrate final concentrations indicated. 2 days later, the concentration of IL-21 in the supernatant was examined with ELISA. 𝑛=3, *𝑃<0.05 versus 0 μM.