Fenofibrate Inhibited the Differentiation of T Helper 17 Cells In Vitro
Figure 5
Fenofibrate reduced the activation of STAT3 in the Th17 differentiation system. (a) Total T cells were isolated from mouse spleens and induced differentiation to Th17 cells with 10 ng/mL TGF-β and 40 ng/mL IL-6 plus 20 μM fenofibrate or solute control. 24 and 48 hours later, the phosphorylation state of STAT3 was analyzed with western blot. Data shown here represent one of three independent experiments. Graphs in (b) indicate the statistic significance of STAT3 phosphorylation state relative to the control group. -4, * versus control.
