Hepatic Cerebroside Sulfotransferase Is Induced by PPARα Activation in Mice

Figure 2

Changes in hepatic expression of sulfatide-metabolizing enzymes by fenofibrate treatment. Open and closed bars indicate mice treated without or with 0.1% fenofibrate, respectively. Data are expressed as mean ± SD (𝑛=6/group). *𝑃<0.05; **𝑃<0.01. (a) The mRNA levels of CST, ARSA, CGT, and GALC. Hepatic mRNA levels were normalized to those of GAPDH and then expressed as fold changes relative to those of Ppara (+/+) mice treated with a control diet. (b) Immunoblot analysis. Actin was used as the loading control. Band intensities were measured densitometrically, normalized to those of actin, and then expressed as fold changes relative to those of Ppara (+/+) mice treated with a control diet.