Modulation of Preactivation of PPAR-β on Memory and Learning Dysfunction and Inflammatory Response in the Hippocampus in Rats Exposed to Global Cerebral Ischemia/Reperfusion

Figure 3

GW0742 inhibits the GCIRI-induced increase of mRNA expression of PPAR-β in hippocampus of rats (𝑛=4). The relative mRNA level of PPAR-β was normalized to endogenous β-actin mRNA for each sample. M: DNA marker, 1: vehicle sham group, 2: vehicle model group, 3: GW0742 20 model group, 4: GW0742 60 model group, and 5: GW0742 180 model group. Dates are expressed as mean ± SD of four individual experiments. **𝑃<0.01 compared with vehicle sham group; ^#𝑃<0.05,   ^##𝑃<0.01 compared with vehicle model group; ^Δ𝑃<0.05 compared with GW0742 20 model group.