Review Article

Peroxisome Proliferator-Activated Receptor Gamma and Regulations by the Ubiquitin-Proteasome System in Pancreatic Cancer

Figure 2

The role of ubiquitination and PPARγ in the PI3K-AKT and MAPKs signaling pathways. Proteins that are regulated by ubiquitination are depicted as yellow cycles. Examples of regulation of these pathways by PPARγ include transcriptional activation of phosphatase PTEN and antagonism of the transcriptional activity of NF-κB.
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