Rhein Reduces Fat Weight in db/db Mouse and Prevents Diet-Induced Obesity in C57Bl/6 Mouse through the Inhibition of PPARγ Signaling

Figure 3

Rhein improves lipid profiles and glucose tolerance test in high-fat diet-induced obese C57BL/6 mice. (a) TC, TG, HDH-c, and LDL-c contents. (b) Fasting blood glucose levels (0 min) and glucose tolerance test (GTT). The mice were fasted for 12 hours before measuring blood glucose levels as 0 min. Then 1 g/kg body weight of glucose was injected intraperitoneally and glucose levels were tested at regular intervals of 15, 30, 60, and 90 min. Data are presented as mean ± SE for 7 mice per group. HF: high-fat diet. RH: rhein. *𝑃<0.05, **𝑃<0.01 versus HF group.

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