Cinchonine Prevents High-Fat-Diet-Induced Obesity through Downregulation of Adipogenesis and Adipose Inflammation

Figure 5

Schematic of the WNT10b and galanin-mediated signaling pathways linked to adipogenesis. In HFD model, increased SFRP5 and DKK2 inhibit WNT10b to combine with LRP and frizzed receptor. Decreased WNT10b signal transduction increases the phosphorylation of β-catenin thus reducing the amount of β-catenin transported to nucleus. In HFD model, decreased amount of β-catenin in nucleus cannot inhibit the activity of PPARγ resulting in the stimulation of adipogenesis. The HFD also increases gene expression in the galanin-mediated signaling pathway. More galanin binds to its receptors, resulting in increased phosphorylation of ERK, which further induces Cyc-D. Increased Cyc-D promotes more E2F1 to bind to DP that stimulates the expression of PPARγ2, C/EBPα, and its target genes.