Prenatal Rosiglitazone Administration to Neonatal Rat Pups Does Not Alter the Adult Metabolic Phenotype

Table 2

Effect of RGZ on fatty acid synthesis. At 19 weeks, the fraction of de novo lipogenesis and incorporation into the tissues were analyzed by deuterium labeling and mass spectrometry. There were no significant differences (𝑃>0.05) in the fraction of de novo synthesis of palmitate molecules in the RGZ- and dexamethasone-treated groups compared with the controls. m1 = fraction of isotopomer molecules with one deuterium substitution, m2 = fraction of isotopomer molecules with two deuterium atoms. 𝑁=24 (6 in each group).

Group	m2/m1	Deuterium enrichment (%)	Fraction of new palmitate molecules
Control	0.36	0.04	0.28
RGZ 0.3 mg/kg	0.41	0.04	0.28
RGZ 3 mg/kg	0.35	0.04	0.25
Dexamethasone 0.25 mg/kg	0.37	0.04	0.30