PPARs in Regulation of Paraoxonases: Control of Oxidative Stress and Inflammation Pathways

<table>Proposed mechanism for the hydrolysis of oxidized lipids in macrophages by PON1 to yield lysophosphatidylcholine. Oxidized lipids with hydroxyl groups at the 5′ position could be lactonized by PON1 to yield lysophosphatidylcholine and the corresponding <i>δ</i>-valerolactone products. The latter can be hydrolyzed again by PON1 to yield the corresponding 5-hydroxycarboxylic acid.</table>

PPAR Research

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Figure 4

Figure 4: PPARs in Regulation of Paraoxonases: Control of Oxidative Stress and Inflammation Pathways 