Leptin Antagonizes Peroxisome Proliferator-Activated Receptor-γ Signaling in Growth Plate Chondrocytes
Figure 3
Leptin suppresses the PPAR inhibitory effects on growth plate chondrocytes by activating MAPK/ERK signaling pathway. ((a), (b)) Gene expression of chondrogenic differentiation marker Col2a1 (a) and terminal differentiation marker Col10a1 (b) in chondrocytes treated with ciglitazone and leptin for 5 days in the presence and absence of PD98059. T3 was added to induce the chondrocyte terminal differentiation. Data are presented as the leptin-induced fold changes in ciglitazone-treated chondrocytes, normalized to the expression in cells treated with ciglitazone alone. * versus expression changes in the chondrocytes untreated with PD98059.
