The PPARα/γ Agonist, Tesaglitazar, Improves Insulin Mediated Switching of Tissue Glucose and Free Fatty Acid Utilization In Vivo in the Obese Zucker Rat

Table 7

Glycogen content (µmol/g) and synthesis rate 𝑅_gly (µmol/100 g/min) in red skeletal muscle.

Group	Lean		Obese		Tesaglitazar
State	Basal	ClampL	Basal	ClampL	Basal	ClampL
Content	33±4	40±2	43±7	49±2	33±3^∗	41±2
𝑅gly	0.25±0.05	3.53±0.91	0.38±0.07	1.86±0.55^†	0.20±0.02	3.99±0.31^‡‡

Results are mean ± SE (𝑛 = 4–8). Groups of animals were studied either in the basal state or during isoglycemic clamps performed at physiological levels of hyperinsulinemia suited to each group (insulin infusion rates as for ClampL in Study 2, defined in Table 3). Data represent values obtained by averaging red gastrocnemius and red quadriceps muscles. Basal state differences; ^∗𝑃<0.05 versus Obese. Response to insulin (ClampL-Basal) differences; ^†𝑃<0.05 Obese versus Lean, and ^‡‡𝑃<0.01, Tesaglitazar versus Obese.