Interaction Effects of the Leu162Val PPARα and Pro12Ala PPARγ2 Gene Variants with Renal Function in Metabolic Syndrome Population
Table 7
Comparison of anthropometric, HOMA index, and biochemical characteristics of subjects between different groups of Leu162Val PPARα genotypes in two subdivided groups according to age.
Parameters
Age < 60 years
Age ≥ 60 years
Leu162Val PPARα
Leu162Val PPARα
L/L ( = 345)
X/V ( = 69)
P
L/L ( = 96)
X/V ( = 12)
P
Age (years)
36 (28–45)
36 (28–43)
0.622
62 (60–67)
62 (60–69)
0.957
SBP (mmHg)
125 (120–140)
130 (120–135)
0.389
130 (120–140)
125 (120–135)
0.178
DBP (mmHg)
80 (80–85)
80 (80–85)
0.859
80 (80–85)
80 (75–80)
0.159
BMI (kg/m2)
25.7 (24.3–28.3)
26.6 (24.3–29.4)
0.147
26.9 (24.5–27.7)
26.8 (24.5–28.6)
0.965
WC (cm)
93.0 (82.0–97.0)
94.0 (87.5–98.5)
0.060
93.0 (85.5–97.5)
92.0 (81.5–98.5)
0.934
TG (mmol/L)
1.47 ± 0.73
1.47 ± 0.73
0.985
1.59 ± 0.69
1.24 ± 0.72
0.095
TC (mmol/L)
4.73 (4.19–5.49)
4.72 (4.14–5.42)
0.870
4.89 (4.48–5.68)
4.63 (3.95–5.27)
0.127
cLDL (mmol/L)
3.09 (2.61–3.71)
3.17 (2.57–3.64)
0.847
3.31 (2.91–3.84)
3.06 (2.39–3.79)
0.261
cHDL (mmol/L)
1.13 (0.88–1.29)
1.14 (0.92–1.34)
0.305
1.03 (0.88–1.27)
1.07 (0.76–1.33)
0.663
FPG (mmol/L)
5.96 ± 1.75
5.46 ± 1.33
0.026
6.34 ± 1.90
4.73 ± 0.84
0.005
FPI (mIU/L)
9.83 (7.12–12.88)
9.05 (6.78–12.28)
0.510
9.68 (7.12–12.89)
7.38 (5.54–11.04)
0.039
HOMA-β%
86 (64–100)
94 (77–111)
0.017
83 (56–99)
110 (84–131)
0.003
HOMA-S%
77 (54–109)
84 (61–118)
0.262
79 (53–111)
106 (72–142)
0.025
HOMA-IR
1.2 (0.9–1.8)
1.2 (0.9–1.7)
0.322
1.3 (0.9–1.9)
1.0 (0.8–1.4)
0.037
Cr (μmol/L)
97.1 ± 40.7
95.3 ± 34.5
0.731
108.4 ± 44.0
113.3 ± 54.1
0.722
Urea (mmol/L)
5.99 ± 3.87
4.94 ± 1.82
0.028
7.36 ± 4.83
4.65 ± 1.94
0.058
UA (μmol/L)
307 (248–385)
292 (233–341)
0.090
319 (237–377)
265 (217–352)
0.247
GFR (mL/min)
89.5 (72.7–105.1)
105.5 (91.8–117.2)
0.004
64.2 (47.1–75.1)
68.2 (56.9–82.1)
0.475
L, Leu; V, Val; X/V: Leu/Val and Val/Val. SBP: systolic blood pressure, DBP: diastolic blood pressure; BMI: body mass index; WC: waist circumference; TG: triglycerides; TC: total cholesterol; cHDL: high density lipoprotein cholesterol; cLDL: low density lipoprotein cholesterol; FPG: fasting plasma glucose; FPI: fasting plasma insulin; HOMA-β%: % β-cell function; HOMA-S%: % cell insulin sensitivity; HOMA-IR: insulin resistance; Cr: creatinine; UA: uric acid; GFR: glomerular filtration rate.
