Peroxisome Proliferator-Activated Receptor Genetic Polymorphisms and Nonalcoholic Fatty Liver Disease: Any Role in Disease Susceptibility?

Figure 1

Meta-analysis of the effect of the Pro12Ala PPARγ variant on the risk of NAFLD in published studies. The odds ratio (ORs) and the corresponding 95% confidence interval (c.i.) limits (lower and upper) are calculated by random effects meta-analysis (Mantel-Haenszel; M-H) for nonalcoholic fatty liver disease (NAFLD) according to the Pro12Ala variant (12Ala positive versus 12Pro/Pro genotype). In the “Study” is cited the first author of the study. “Events” indicate the number of patients with NAFLD who carry a genotype (e.g., 36 positive for 12Ala allele) while “Total” indicates the sum of patients and controls with the same genotype (e.g., 87 is the sum of NAFLD patients and controls who carry the 12 allele). In the graph, numbers indicate OR and filled diamond express random effect. The symbol size is proportional to the weight of the study.