Peroxisome Proliferator-Activated Receptor Genetic Polymorphisms and Nonalcoholic Fatty Liver Disease: Any Role in Disease Susceptibility?

Table 2

Characteristics of the studies on the association between the Pro12Ala variant of PPAR𝛾 and nonalcoholic fatty liver disease.

First author, year	Ref.	Ethnicity, country	Study design, sample size (𝑁)	Patients characteristics	Liver biopsy (𝑁)	Female sex, 𝑁 (%)
Dongiovanni, 2010	[25]	Caucasian, Italy	Case-control; 𝑁=202	Histologically proven NAFLD	𝑁=202	41 (20)
Gawrieh, 2011	[51]	Caucasian, USA	Case-control; 𝑁=212	Histologically proven NAFLD	𝑁=212	145 (68)
Gupta, 2011	[52]	Asian, India	Case-control; 𝑁=98	Diagnosis based on ultrasound	𝑁=71	32 (33)
Rey, 2010	[53]	Caucasian, Germany	Case-control; 𝑁=263	Histologically proven NAFLD	𝑁=263	Not specified
Yang, 2012	[54]	Asian, China	Case-control; 𝑁=436	Diagnosis based on ultrasound	—	280 (64)

Ref: reference number; 𝑁: number; NAFLD: nonalcoholic fatty liver disease.