The Liver X Receptor in Correlation with Other Nuclear Receptors in Spontaneous and Recurrent Abortions
Figure 1
Sections of LXR expression in the syncytiotrophoblast and decidua of placentas from spontaneous abortion ((a), (d)), recurrent miscarriage ((b), (e)), and in regular pregnancies ((c), (f)). (i) shows Isotype control for LXR from colon tissue. Box plots represent the LXR expression in the placental syncytiotrophoblast (g) and decidua (h) of spontaneous abortion, recurrent miscarriages, and control placentas derived immunohistochemically. The boxes display the range between the 25th and 75th percentile and the red horizontal line indicates the median. The bars represent the 5th and 95th percentiles. Circles indicate values which are more than 1.5 times the box length. LXR expression in the syncytiotrophoblast of spontaneous abortion is significantly reduced in comparison to LXR expression in the syncytiotrophoblast of control placentas (). In the syncytiotrophoblast of recurrent miscarriages a downregulation of LXR expression could be detected, however this trend was not significant (). In decidua, we identified significant downregulation of LXR in both spontaneous abortion and recurrent miscarriages with values of 0.003 and 0.008, respectively. The Mann-Whitney- test was used for evaluation of two independent groups.
