Neuroprotective Properties of a Novel Non-Thiazoledinedione Partial PPAR-γ Agonist against MPTP
Figure 5
LSN862 (LSN) prevented MPTP-induced microglial activation. Mice brains were evaluated 21 days after completing MPTP or PBS challenge and 24 hrs after daily treatment with LSN. (mean ± SEM; per group). (a) Coronal images at the level of the substantia nigra (SN) immunostained for MAC-1 (cd11b). Insets correspond to high magnification images. Scale bar: low magnification = 100 μm, high magnification = 25 μm. (b) Quantification of nigral MAC-1 immunoreactivity. ANOVA Fisher’s LSD post hoc, # (vehicle + PBS versus vehicle + MPTP), * (vehicle + MPTP versus 30 mg/kg LSN + MPTP).
