Neuroprotective Properties of a Novel Non-Thiazoledinedione Partial PPAR-γ Agonist against MPTP

Figure 6

LSN862 (LSN) inhibited MPTP-mediated astrogliosis. Mice brains were evaluated 21 days after completing MPTP challenge and 24 hrs after daily treatment with LSN. (a) Images at the level of the substantia nigra (SN) immunostained for GFAP. Insets correspond to high magnification images. Scale bar: low magnification = 100 μm, high magnification = 25 μm. (b) Quantification of nigral GFAP immunoreactivity (means ± SEM; 𝑛=4--7 per group); ANOVA (Fisher’s LSD post hoc), ^#𝑃<0.05 (vehicle + PBS versus vehicle + MPTP), *𝑃<0.05 (vehicle + MPTP versus 30 mg/kg LSN + MPTP).

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