Neuroprotective Properties of a Novel Non-Thiazoledinedione Partial PPAR-γ Agonist against MPTP

Table 1

Striatal MPTP metabolism is not affected by LSN862. C57BL/6 mice received MPTP (i.p. 30 mg/kg × 5 days) or MPTP + LSN862 (p.o. 30 mg/kg). Mice were euthanized 15 or 90 minutes after the last dose of MPTP and 24 hrs after the last dose of LSN. Groups were for 15 min vehicle + MPTP (𝑛=6), 30 mg/kg + LSN + MPTP (𝑛=6); for 90 min: vehicle + MPTP (𝑛=7), 30 mg/kg LSN + MPTP (𝑛=6). No significant differences between groups were detected (two-tailed independent 𝑡-tests). Values represent mean ± SEM.

Measure	MPTP only (15 min)	MPTP + LSN862 (15 min)	MPTP only (90 min)	MPTP + LSN862 (90 min)
MPP^+ level (𝜇g/g tissue)	4.14±2.49	4.37±0.72	3.61±0.56	2.11±0.20
MAO-B activity (RLU/𝜇g protein)	3760.62±299.34	3320.71±229.16	4421.25±364.16	3824.43±252.66